5 Best Multibagger Penny Stocks to Invest In

In this article, we will list the 5 Best Multibagger Penny Stocks to Invest In. Please visit 10 Best Multibagger Penny Stocks to Invest In if you would like to see the extended list and the methodology behind it.

5. Taysha Gene Therapies, Inc. (NASDAQ:TSHA)

Share Price: $4.30

Stock Upside Potential: 198.67%

Number of Hedge Fund Holders: 32

Taysha Gene Therapies, Inc. (NASDAQ:TSHA) is one of the best multibagger penny stocks to invest in. On March 25, Cantor Fitzgerald reiterated an Overweight rating on Taysha Gene Therapies (NASDAQ:TSHA) with a $19 price target.

The positive stance is in response to the company making significant progress on the development of TSHA-102, an investigational gene transfer therapy in evaluation for Rett syndrome. Chief Executive Officer Sean Noland has already confirmed they are bolstering commercial-readiness efforts ahead of potential registration.

Photo by George Morina on Pexels

Taysha Gene Therapies has also received FDA clearance to initiate the ASPIRE trial in 3 patients to support a potential broad label in the second quarter. The milestone follows a favorable tolerability profile, continued patient enrollment, and a well-defined regulatory trajectory.

Amid TSHA-102 development progress, Taysha Gene Therapies reported a net loss of $109 million, or $0.34 per share, for the year ended December 31, 2025. It was a significant increase from a net loss of $89.3 million, or $0.36 a share, for the year ended 2024. The wider-than-expected net loss was due to an increase in research and development expenses, which came in at $86.4 million, up from $66 million in 2024.

Taysha Gene Therapies, Inc. (NASDAQ:TSHA) is a clinical-stage biotechnology company developing adeno-associated virus (AAV)-based gene therapies for severe monogenic central nervous system diseases. Their lead candidate, TSHA-102, uses miRNA-regulatory technology to treat Rett syndrome, aiming to address the disease’s underlying genetic cause.