13G Filing: Palo Alto Investors and Epizyme Inc. (NASDAQ:EPZM)

Page 5 of 8 – SEC Filing

1. Names of Reporting Persons.

Palo Alto Healthcare Master Fund II, L.P.

2. Check the Appropriate Box if
a Member of a Group (See Instructions)

(a)

(b) X

3. SEC Use Only

4. Citizenship or Place of Organization
Cayman Islands

Number of

Shares

Beneficially

Owned by

Each Reporting

Person With:

5. Sole Voting Power 0

6. Shared Voting Power 2,948,996

7. Sole Dispositive Power 0
8. Shared Dispositive Power 2,948,996

9. Aggregate Amount Beneficially
Owned by Each Reporting Person 2,948,996

10. Check if the Aggregate Amount
in Row (9) Excludes Certain Shares (See
Instructions) ______

11. Percent of Class Represented
by Amount in Row (9) 5.06%

12. Type of Reporting Person (See
Instructions) PN

5

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