13 Best Fortune 500 Dividend Stocks to Invest In

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1. Pfizer Inc. (NYSE:PFE)

% Dividend Yield: 7.20%

Pfizer Inc. (NYSE:PFE) ranks among the 13 best Fortune 500 dividend stocks to invest in. The company raises its Adjusted Diluted EPS guidance and raises its total savings goal amid a revenue increase in Q2 2025.

Pfizer Inc. (NYSE:PFE)’s second-quarter results were reported on August 5, 2025, where it highlighted a year-over-year increase in revenue of 10%, reaching $14.7 billion. The revenue growth was partly contributed to by continued strong demand and growth for the Vyndaqel family of drugs due to increased diagnosis and treatment rates.

Following the strong quarter, the company announced raising its full-year 2025 adjusted diluted EPS guidance by $0.10 to a range of $2.90 to $3.10. Furthermore, the company raised its cost-cutting target with an additional $1.7 billion in savings through 2027. This increase raised the total savings goal to $7.7 billion. The company anticipates realizing approximately $4.5 billion of these savings by the end of 2025.

Pfizer Inc. (NYSE:PFE) tops our list of 13 best Fortune 500 dividend stocks to invest in, by offering an attractive dividend yield of 7.20%.

Pfizer Inc. (NYSE:PFE) is a global pharmaceutical and biotechnology corporation, headquartered in New York. The company was formed in 1849 and focuses on developing and manufacturing a wide range of medicines and vaccines for various therapeutic areas, including oncology, cardiology, and immunology.

While we acknowledge the potential of PFE to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than PFE and that has 100x upside potential, check out our report about this cheapest AI stock.

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