12 Most Profitable Large Cap Stocks to Buy Right Now

3. Zoetis Inc. (NYSE:ZTS)

Market Capitalization as of November 21: $53.79 billion

TTM Net Income as of November 21: $2.65 billion

TTM Net Income Margin as of November 21: 28.21%

Number of Hedge Fund Holders: 75

Average Upside Potential as of November 21: 57.30%

Zoetis Inc. (NYSE:ZTS) is one of the most profitable large cap stocks to buy right now. On November 18, Stifel analyst Jonathan Block lowered the firm’s price target on Zoetis to $130 from $140 and kept a Hold rating on the shares. After the release of the company’s Q3 2025 results, Street’s revenue forecasts for both 2026 and 2027 were lowered. This revision eased some of Stifel’s previous concerns about overly optimistic expectations, but the firm still believes that Street’s revenue outlook for 2026 may be aggressive.

In these Q3 2025 earnings results, Zoetis reported a total revenue of $2.4 billion, which showed 4% organic operational growth. Adjusted net income reached $754 million, growing 9% on an organic operational basis. This led to an adjusted diluted EPS growth of 12% organically. The company’s performance was mixed across its segments.

The company noted that it has revised its full-year revenue guidance to a more measured view of macro and operational trends, setting it at $9.4 to $9.475 billion, representing 5.5% to 6.5% organic operational growth. Full-year adjusted net income guidance is set at $2.8 to $2.84 billion (5.5% to 7% organic operational growth), with adjusted diluted EPS guidance at $6.30 to $6.40

Zoetis Inc. (NYSE:ZTS) discovers, develops, manufactures, and commercializes animal health medicines, vaccines, diagnostic products and services, biodevices, genetic tests, and precision animal health products in the US and internationally.