12 Best High Short Interest Stocks With Highest Upside Potential

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6. Apogee Therapeutics Inc. (NASDAQ:APGE)

Average Upside Potential: 48.85%

Apogee Therapeutics Inc. (NASDAQ:APGE) is one of the best high short interest stocks with highest upside potential. On May 27, Apogee Therapeutics secured $1.3 billion in non-dilutive financing from Blackstone Life Sciences to fund Phase 3 development and commercialization of zumilokibart. The deal includes $800 million in synthetic royalties and $500 million in senior debt, which, alongside existing cash, allows Apogee to reach profitability without further equity raises.

The funding is milestone-based, tied to Phase 3 progress and FDA approval. Blackstone’s commitment (the largest royalty financing for a pre-Phase 3 program) underscores its confidence in zumilokibart’s potential as a first-line treatment for atopic dermatitis and other inflammatory conditions.

Management noted that this partnership provides the capital flexibility needed to advance zumilokibart as a multi-indication therapy. By securing this financial foundation, Apogee Therapeutics Inc. (NASDAQ:APGE) aims to accelerate its pipeline and successfully transition from clinical innovation to commercial launch.

Apogee Therapeutics Inc. (NASDAQ:APGE) operates as a biotechnology company, offering treatment of atopic dermatitis, chronic obstructive pulmonary disease, and related inflammatory and immunology indications.

While we acknowledge the potential of APGE to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than APGE and that has 100x upside potential, check out our report about the cheapest AI stock.

Click to continue reading and see the 5 Best High Short Interest Stocks With Highest Upside Potential.

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