11 Best High Short Interest Stocks With Biggest Upside Potential

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7. Alphatec Holdings Inc. (NASDAQ:ATEC)

Number of Hedge Fund Holders: 40

Average Upside Potential: 64.37%

Alphatec Holdings Inc. (NASDAQ:ATEC) is one of the best high short interest stocks with biggest upside potential. On January 27, TD Cowen lowered its price target for Alphatec to $20 from $27 while maintaining a Buy rating following a transfer of coverage. The firm suggested that the current market expectations do not fully appreciate the company’s growth vectors, such as its recent 2026 revenue outlook of $890 million and the acquisition of exclusive US rights to Theradaptive’s OsteoAdapt bone graft. The firm believes that this undervaluation creates potential for upward revisions to financial estimates as Alphatec continues to execute on its pure-play spine medtech strategy.

Earlier on January 12, Alphatec Holdings Inc. (NASDAQ:ATEC) and Theradaptive entered a landmark partnership granting Alphatec exclusive US commercial rights to market and distribute OsteoAdapt, a breakthrough osteoinductive bone graft for spinal fusion.

Announced alongside Theradaptive’s Series B investment round, the agreement is designed to deliver significant long-term value through a structure of upfront and milestone payments coupled with perpetual royalties. This collaboration aims to disrupt the $10 billion US spine biologics market by leveraging Alphatec’s commercial network to provide a protein-engineered regenerative solution that triggers natural bone growth.

Alphatec Holdings Inc. (NASDAQ:ATEC) is a medical technology company that designs, develops, and advances technologies for the surgical treatment of spinal disorders in the US and internationally.

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