10 Top Stocks Fund Managers Are Loading Up On in 2026

9. AstraZeneca PLC (NYSE:AZN)

Number of Hedge Fund Holders: 52

AstraZeneca PLC (NYSE:AZN) is one of the 10 top stocks fund managers are loading up on in 2026.

On March 27, 2026, Deutsche Bank maintained a Sell rating on AstraZeneca PLC (NYSE:AZN). The firm’s analyst kept a price target of £115 on the stock. On the other hand, in a more recent update, Guggenheim raised the firm’s price target on AstraZeneca PLC (NYSE:AZN) from 16,000 GBp to 16,500 GBp. Analyst Seamus Fernandez kept a Buy rating on the company’s stock. The firm made the adjustment following an update of its financial model ahead of Q1 earnings.

In another development, on March 31, 2026, AstraZeneca PLC (NYSE:AZN) announced positive Phase III results for efzimfotase alfa – an investigational enzyme replacement therapy for hypophosphatasia. The program covered 196 patients across 22 countries to provide a lower-volume, less frequent dosing alternative to Strensiq. The MULBERRY trial met all primary endpoints in treatment-naive pediatric patients, showing significant bone health improvements. In addition, the CHESTNUT study confirmed that children who switched from Strensiq maintained clinical benefits. The HICKORY trial missed its primary mobility endpoint in adults but showed meaningful functional gains in pediatric-onset subgroups.

Founded in 1999 through the merger of Astra AB and Zeneca Group, AstraZeneca PLC (NYSE:AZN) is a global biopharmaceutical leader with headquarters in the United Kingdom. The company focuses on the discovery, development, manufacture, and commercialization of prescription medicines.