10 NYSE Stocks with the Highest Upside Potential

6. Inspire Medical Systems, Inc. (NYSE:INSP)

Analyst Upside: 61.29%

Number of Hedge Fund Holders: 37

Inspire Medical Systems, Inc. (NYSE:INSP) is one of the top NYSE stocks with the highest upside potential. Piper Sandler lowered the firm’s price target on Inspire Medical Systems, Inc. (NYSE:INSP) to $150 from $233 on August 5, keeping an Overweight rating on the shares.

The rating update came after the company’s quarterly results, with the firm stating that while Inspire Medical Systems, Inc. (NYSE:INSP) reported better-than-feared fiscal Q2 2025 results, the focus of the EPS call was on the company’s revised FY2025 guidance.

The guidance was considerably lowered to take into account a number of headwinds, a majority of which are associated with the Gen 5 rollout.

The firm added that while it had suspected that it could see a downward revision, it was disappointed by the magnitude of the cut to both the top and bottom-line guide.

Inspire Medical Systems, Inc. (NYSE:INSP) is a medical technology company that develops and commercializes innovative, minimally invasive solutions for obstructive sleep apnea. The company offers Inspire therapy, which includes implantable components with a pressure-sensing lead, a stimulation lead, and a neurostimulator, operable through a remote control.