10 Most Profitable NYSE Stocks to Buy Now

8. Eli Lilly and Company (NYSE:LLY)

TTM Net Income: $11.11 billion

Number of Hedge Fund Holders: 119

Eli Lilly and Company (NYSE:LLY) is one of the top most profitable NYSE stocks to buy now. On August 7, Leerink downgraded Eli Lilly and Company (NYSE:LLY) to Market Perform from Outperform with a $715 price target.

The rating update came after Eli Lilly and Company (NYSE:LLY) posted its fiscal Q2 2025 earnings the same day, with revenue growing 38% to $15.56 billion, driven primarily by volume growth from Zepbound and Mounjaro.

Eli Lilly and Company (NYSE:LLY) also raised the midpoint of its 2025 full-year revenue guidance by $1.5 billion, taking it to the $60 billion to $62 billion range. It also raised its reported EPS guidance to be in the $20.85 to $22.10 range.

Eli Lilly and Company (NYSE:LLY) develops, manufactures, discovers, and sells pharmaceutical products. These products span oncology, diabetes, immunology, neuroscience, and other therapies.