10 Hottest Mega-Cap Stocks of 2025

​6. Advanced Micro Devices, Inc. (NASDAQ:AMD)

Market Capitalization: $348.75 billion

Year-to-Date Performance: 78.15%

Number of Hedge Fund Holders: 113

​Advanced Micro Devices, Inc. (NASDAQ:AMD) is one of the Hottest Mega-Cap Stocks of 2025. On October 6, Advanced Micro Devices, Inc. (NASDAQ:AMD) announced a strategic partnership with OpenAI to deploy 6 Gigawatts of AMD GPUs. These GPUs will power OpenAI’s next-generation AI Infrastructure.

​This is a multigeneration agreement with the first gigawatt deployment of AMD Instinct MI450 GPUs expected to begin in the second half of 2026. The stock has gained more than 7.5% in just a week since the announcement, and several Wall Street analysts have raised their price targets on Advanced Micro Devices, Inc. (NASDAQ:AMD).

​On October 10, Joshua Buchalter from TD Cowen raised the firm’s price target on the stock from $195 to $270, while reiterating a Buy rating. More recently, on October 13, Vijay Rakesh from Mizuho Securities also raised the price target on Advanced Micro Devices, Inc. (NASDAQ:AMD), while maintaining a Buy rating on the stock.

​Advanced Micro Devices, Inc. (NASDAQ:AMD) is an international semiconductor company that specializes in high-performance computing, graphics, and visualization technologies.