10 Best Up and Coming Stocks with Huge Upside Potential

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1. Janux Therapeutics Inc. (NASDAQ:JANX)

Number of Hedge Fund Holders: 39

Average Upside Potential as of September 12: 212.37%

Janux Therapeutics Inc. (NASDAQ:JANX) is one of the best up and coming stocks with huge upside potential. On September 10, Truist initiated coverage of Janux Therapeutics with a Buy rating and $100 price target. Truist believes that the company’s masking platform has the potential to overcome the limitations of T-cell engagers in solid tumors by improving safety and efficacy through tumor-activated masking.

For Q2 2025, Janux reported a net loss of $33.9 million, which is an increase from the $6.0 million net loss in Q2 2024. This was primarily due to increased expenses. R&D expenses were $34.7 million, compared to $14.9 million a year earlier, and G&A expenses were $10.5 million, up from $7.8 million in Q2 2024.

The company also announced that it received a $10 million milestone payment from Merck after the first patient was dosed in a lead collaboration program. Janux is advancing its pipeline of novel immunotherapies using its proprietary TRACTr, TRACIr, and ARM platforms. Both JANX007 and JANX008 are currently enrolling patients in their respective Phase 1 clinical trials.

Janux Therapeutics Inc. (NASDAQ:JANX) is a clinical-stage biopharmaceutical company that develops immunotherapies based on Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms technology to treat patients with cancer.

While we acknowledge the potential of JANX to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than JANX and that has 100x upside potential, check out our report about this cheapest AI stock.

READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now.

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