10 Best Up and Coming Stocks with Huge Upside Potential

2. Apogee Therapeutics Inc. (NASDAQ:APGE)

Number of Hedge Fund Holders: 36

Average Upside Potential as of September 12: 155.45%

Apogee Therapeutics Inc. (NASDAQ:APGE) is one of the best up and coming stocks with huge upside potential. On August 28, BofA analyst Tim Anderson raised the firm’s price target on Apogee Therapeutics to $87 from $78, while keeping a Buy rating on the shares, citing estimate changes following Q2 2025 results.

The Q2 2025 financial results showed that Apogee Therapeutics had a strong cash position of $621.2 million in cash, cash equivalents, and marketable securities at the end of the quarter. The financial runway is expected to support operations into Q1 2028.

Apogee announced positive 16-week topline data from Part A of its Phase 2 APEX trial for APG777, which is a potential best-in-class treatment for moderate-to-severe atopic dermatitis/AD. The trial met all primary and key secondary endpoints, with APG777 demonstrating a 71% reduction in Eczema Area and Severity Index/EASI from baseline, compared to 33.8% for placebo.

Apogee Therapeutics Inc. (NASDAQ:APGE) is a clinical-stage biotechnology company that develops novel biologics for the treatment of atopic dermatitis/AD, asthma, eosinophilic esophagitis/EoE, chronic obstructive pulmonary disease/COPD, and other inflammatory and immunology indications.