10 Best Up and Coming Stocks with Huge Upside Potential

5. Centessa Pharmaceuticals (NASDAQ:CNTA)

Number of Hedge Fund Holders: 36

Average Upside Potential as of September 12: 53.06%

Centessa Pharmaceuticals (NASDAQ:CNTA) is one of the best up and coming stocks with huge upside potential. On September 9, LifeSci Capital analyst Francois Brisebois reiterated a Buy rating on Centessa Pharmaceuticals and set a price target of $39.00.

In Q2 2025, Centessa Pharmaceuticals reported that the company had $404.1 million in cash and investments, which is projected to fund its operations into mid-2027. The company’s R&D expenses increased to $42.7 million in Q2 2025, up from $32.8 million in Q2 2024. This led to a wider net loss of $50.3 million in Q2 2025, compared to a net loss of $43.8 million in Q2 2024.

Centessa also provided updates on its orexin receptor 2 (OX2R) agonist pipeline. Its lead candidate, ORX750, is progressing in the Phase 2a CRYSTAL-1 study for the treatment of narcolepsy types 1 and 2 (NT1 and NT2) and idiopathic hypersomnia. Data from this study is anticipated within the year. Additionally, the Phase 1 trial for ORX142 began following the FDA’s clearance of its Investigational New Drug application in June 2025, with data expected within the year.

Centessa Pharmaceuticals (NASDAQ:CNTA) is a clinical-stage pharmaceutical company that discovers, develops, and delivers medicines.