10 Best NASDAQ Stocks Under $50 to Buy

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1. Prothena Corporation plc (NASDAQ:PRTA)

Upside potential as of June 16, 2025: 329.09%

Roche, a partner of Prothena Corporation plc (NASDAQ:PRTA), has announced plans to initiate Phase 3 development of prasinezumab for early-stage Parkinson’s disease. Although the company faced a setback with birtamimab, which failed to meet the desired result, the giant is keen on taking things forward with new developments.

This decision comes after the company’s favorable Phase 2b PADOVA results and sustained follow-up data highlighting clinical benefit when prasinezumab solution and symptomatic treatment are used together. This creates exciting opportunities for the company, which has a potential upside of over 300%, as the one-year price target of $24.29 by Yahoo Finance suggests.

One thing that is most important for companies such as Prothena Corporation plc (NASDAQ:PRTA) is the determination to stand strong despite failures. The company’s strong pipeline, including Alzheimer’s, Parkinson’s, and ATTR-CM candidates, makes us believe that achieving the upside potential isn’t hard to achieve, particularly when the Alzheimer’s Disease market is anticipated to reach $19.3 billion by 2033.

Prothena Corporation plc (NASDAQ:PRTA) is an Ireland-based late-stage clinical biotechnology company that identifies and develops novel therapies for diseases caused by protein dysregulation. Incorporated in 2012, the company focuses on advancing therapies through clinical development, often in collaboration with other organizations.

While we acknowledge the potential of PRTA to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than PRTA and that has 100x upside potential, check out our report about this cheapest AI stock.

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