Tackling Cancer: Breast Cancer’s Biggest Current & Upcoming Players – Roche Holding Ltd. (ADR) (RHHBY), AstraZeneca plc (ADR) (AZN), ImmunoGen, Inc. (IMGN)

Page 1 of 2

You Won't Believe Where I Found Yields of Up to 16%As I noted two weeks ago, cancer statistics are both staggering and disappointing. Although cancer deaths per 100,000 people have been on the downswing since 1991 thanks to access to more effective medications and better awareness about the negative health effects of smoking, there is still a lot of research and progress yet to achieve. My focus in this 12-week series is to bring to light both the need for continued research in these fields, as well as highlight ways you can profit from the biggest current and upcoming players in each field.

Last week we took a closer look at prostate cancer’s biggest players. This week I’ll be shifting the focus to the second most-common cancer type: breast cancer.

The skinny on breast cancer
Closely following prostate cancer is breast cancer, which is forecast to be diagnosed in nearly 235,000 people in 2013 — including more than 2,200 men! However, make no mistake about it, excluding for skin cancers, breast cancer is the most common cancer diagnosis that a woman is likely to receive.


Source: Centers for Disease Control and Prevention.

Like we saw with prostate cancer, five-year survival rates have been steadily rising for female breast cancer suffers. In 1975-1977, five-year survival rates were 75%, but have since improved to approximately 90% as 2002-2008 according to the American Cancer Society (link opens PDF). Part of this improvement can be attributed to better public awareness with regard to earlier detection, while other aspects, including better treatment options and a reduction in the use menopausal hormone therapy, which was discovered to contribute to cancer-causing risk, have played their part.

The treatment options for those with breast cancer will vary based on the stage of the disease, but most often involves either breast-conserving surgery or mastectomy (removal of the entire breast). Numerous studies have shown that breast-conserving surgery when combined with radiation compares just as favorably as a mastectomy in terms of long-term survival, but again, each case will vary. Additional treatments may include chemotherapy, hormone therapy, or radiation therapy.

Where investment dollars are headed
Unlike prostate cancer, breast cancer has a number of players in both the early stages and late stages of the disease. Let’s first examine some of the early stage breast cancer players in post-menopausal women.

By far, the most common treatment pathway in early stage breast cancer is through hormonal therapy (assuming the tumor is hormone-receptor positive). This occurs by reducing estrogen production through the use of aromatase inhibitors or blocking the effects of estrogen on cancerous cells with selective estrogen receptor modulators, or SERMs. With a definitive link between estrogen production and cancer cell growth, these treatments revolve specifically around estrogen reduction or suppression.

Aromatase inhibitors: Many aromatase inhibitors have been around for the better part of a decade or longer, so most have come off patent, including Arimidex by AstraZeneca plc (ADR) (NYSE:AZN) and Femara by Novartis AG (ADR) (NYSE:NVS). Both drugs work by temporarily blocking the activity of the aromatase enzyme, which the body uses in order to make estrogen. Aromasin — another aromatase inhibitor made by Pfizer Inc. (NYSE:PFE), which saw its patent expire in 2006 — inactivates the enzyme on a permanent basis.

SERMs: Another way of reducing estrogen’s impact on the body is by creating drugs which bind to estrogen receptors. AstraZeneca plc (ADR) (NYSE:AZN)’s Nolvadex, for example, can act as both an agonist and an antagonist in that it suppresses estrogen’s effects in the breast but can mimic its effects in other parts of the body such as the uterus. Like the above players, Nolvadex came off patent exclusivity a long time ago. Eli Lilly & Co. (NYSE:LLY)‘s Evista, which is protected by patent through 2014, is another SERM, although it’s primarily prescribed for more invasive types of breast cancer that have invaded surrounding tissues.

All told, it’s quite common for early stage breast cancer suffers to be prescribed either Nolvadex or some combination of an aromatase inhibitor and a SERM.

As you might have guessed, there’s also quite a bit of research and money going on into late-stage/metastatic breast cancer. Let’s have a look at some of the most common advanced-stage treatments.

Herceptin: This is Roche Holding Ltd. (ADR) (PINK:RHHBY)‘s wonder drug, approved in 1998 for patients with HER2-positive metastatic breast cancer and responsible for $4.8 billion in global sales in 2011. As you probably inferred, Herceptin targets the HER2 protein by suppressing it and giving standard chemotherapy a chance to be effective. In addition to being approved for metastatic breast cancer, Herceptin gained an additional indication in 2006 for early stage breast cancer following a primary treatment for HER2-positive patients.

Tykerb & Xeloda: In 2007, advanced stage breast cancer suffers got an additional treatment option with the combination of GlaxoSmithKline plc (ADR) (NYSE:GSK)‘s Tykerb and Roche’s Xeloda. The combo was approved as a secondary treatment to be used after patients have tried Herceptin, a taxane, and an anthracycline. Unlike Herceptin, according to the FDA’s press release in 2007, Tykerb is a small molecule able to enter the cancer cell and upset its functionality from within rather than attacking the HER2 protein parts on the outside of the cell as Herceptin does. It’s worth noting, however, that Herceptin sales continue to dominate that of the Tykerb and Xeloda combination.

Page 1 of 2
blog comments powered by Disqus
Insider Monkey Headlines
Insider Monkey Small Cap Strategy
Insider Monkey Small Cap Strategy

Insider Monkey beat the market by 52 percentage points in 24 months Click to see monthly returns in table format!

Lists

10 Most Influential Papers In Economics

Top 8 Biggest Charities in the US

10 Worst Celebrity Career Moves Ever

Top 10 Best Paid Tennis Stars in the World

10 Cities with High Demand for Nurses

6 of the Worst Greeting Card Messages Ever Crafted

6 Ways to Make Money in ArcheAge and Build Your Empire

10 Foods To Eat To Lower Cholesterol Levels

The 10 Most Hated Television Characters of All Time

The 30 Worst Halloween Costume Ideas Ever Brought to Horrible Life

10 Vocational Skills in Demand Today with Jobs Waiting to be Filled

10 Best Places to Visit in Central and South America

The 10 Greatest Empires in History Which Nearly Conquered the World

The 6 Cheapest Boarding Schools In America 2015

5 Clear Reasons LoL is Better than DotA, Continues to Rule MOBAs

The Only 9 Teams with a Chance to Win the Super Bowl

The 15 Most Common Phobias in America that Induce Fits of Panic

Top 6 Least Expensive Tourist Destinations in 2014

Jim Goetz, Peter Fenton, Jim Breyer: Top 6 Venture Investors for 2014

Top 15 Billionaires in 2014

5 Pitfalls To Avoid When Buying a Franchise

Top 20 Medical Schools in the US – 2014 Rankings

4 Business Strategies that Turned Jamie Oliver into the World’s Richest Chef

6 Qualities That Make You A Good Team Player

10 High Paying Seasonal Jobs in America this Holiday Season

The 10 Busiest Shipping Lanes in the World

5 Most Valuable Brands in China

The 10 States with Highest Substance Abuse Rates Crippling Their Populace

The Top 10 Things to Do Before You Die That Will Echo for Eternity

The 10 Best Selling Items on Etsy

Top 10 Things to Do in Tokyo, the Greatest City in the World

10 Mistakes on Social Media that Can Harm You and Will Probably Get You Canned

The 10 Best Cities to Find Jobs in 2014

The 10 Most Controversial Songs Of All Time to Hit (and get Banned from) the Airwaves

The 20 Biggest IPOs in US History

The 10 Best Places to Visit in Mexico that Are Beautiful and Safe

7 Bad Habits that Age You Beyond Your Years

The 40 Best Fortune Cookie Sayings That Will Leave You Bemused, Befuddled, or Beguiled

10 Foods to Eat Before a Workout to Make Every Drop of Sweat Count

The 5 Best Documentaries On Netflix You Must See

The Most Heartwarming and Inspirational Story Of This Halloween Season, It Will Make You Cry and Jump For Joy

10 Best Party Songs of All Time to Bring the House Down With

5 New World Order Conspiracy Theories that Will Strangle the World

The 10 Highest Rated Movies of 2014

The 10 Largest Container Shipping Companies in the World

The 10 Largest Armies in the World: Who Should We Be Afraid Of?

Best Warren Buffett Quotes on Money You Need to Hear

The 10 Highest Suicide Rates by Profession

The 20 Most Underrated Movies of All Time

The 10 Fastest Growing Companies in America

Subscribe

Enter your email:

Delivered by FeedBurner

X

Thanks! An email with instructions is sent to !

Your email already exists in our database. Click here to go to your subscriptions

Insider Monkey returned 47.6% in its first year! Wondering How?

Download a complete edition of our newsletter for free!