While the market of treating chronic diabetic foot ulcers is by no means glamorous, it can still be a very lucrative indication. Some estimates have put the chronic diabetic foot ulcer market at $2 billion annually by 2017. With so much money hanging in the balance, companies are taking notice and attempting to develop better treatments.
One of the companies attempting to develop a better treatment for chronic diabetic foot ulcers is Osiris Therapeutics, Inc. (NASDAQ:OSIR). Earlier this month, Osiris Therapeutics, Inc. (NASDAQ:OSIR) shares more than doubled as the company announced positive data for its CDFU drug Grafix. The study results were very impressive to say the least; the study was stopped early due to the overwhelming efficacy exhibited by the treatment. A main highlight is the fact that 62% of Grafix patients had their wound closed at 12 weeks, compared to only 21% of patients using conventional methods. Clearly, the efficacy in this endpoint was overwhelming. Grafix also achieved all of the secondary endpoints for the trial, and more importantly demonstrated a relatively benign safety record.
Grafix has raised the bar on chronic diabetic foot ulcer treatment. Another company developing treatments for CDFU is Derma Sciences Inc (NASDAQ:DSCI). Derma is developing a treatment called DSC 127, which is currently in phase 3 trials with results expected in 2015.
With this in mind, quickly comparing the data it appears as though Osiris Therapeutics, Inc. (NASDAQ:OSIR) may have just trumped Derma Sciences Inc (NASDAQ:DSCI)’s treatment. In Derma’s phase 2 study, it announced that 54% of patients in its intent to treat group experienced wound closure, compared to 33% in the control group at 12 weeks. Now, Derma Sciences Inc (NASDAQ:DSCI)’s study was a 24-week study, and at week 24, 73.1% of patients using DSC 127 experienced complete wound closure, compared to 48.5% in the control group. Taking into account the data currently available, it appears as though Osiris Therapeutics, Inc. (NASDAQ:OSIR) may have the more effective treatment of the two. However, it will be interesting to see what happens when Derma Sciences Inc (NASDAQ:DSCI) ultimately comes out with its phase 3 data.