Merck & Co., Inc. (MRK): One Potential Roadblock For A Stock Runup

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Merck & Co., Inc.If you own Merck & Co., Inc. (NYSE:MRK) stock, you likely enjoyed the past couple of months. Shares were on a downward trajectory in late 2012 and into early 2013, but the past couple of months are looking much better.

Merck & Co., Inc. (MRK): One Potential Roadblock For A Stock Runup

MRK data by YCharts.

Since February, Merck stock has jumped nearly 14%. Will this nice stock run continue — or is a roadblock right around the corner?

Potential obstacles
It won’t be hard to identify potential obstacles. One that especially stands out is declining revenue from several high-dollar drugs.

Singulair stands at the top of this list. Merck & Co., Inc. (NYSE:MRK) lost U.S. patent protection for the asthma drug in August. Sales for Singulair fell by 67% in the fourth quarter. Merck lost European patent protection for the drug in February, so these numbers will undoubtedly worsen.

Migraine drug Maxalt went off patent in the U.S. in December and loses European market exclusivity in August of this year. Male pattern hair loss drug Propecia also faces generic rivals in 2013. These two drugs combined for more than $1 billion in 2012 sales.

Merck & Co., Inc. (NYSE:MRK) also continues to see lower sales from Remicade and Simponi, which brought in a combined $2.4 billion in 2012. The company reached an agreement with Johnson & Johnson (NYSE:JNJ) in 2011 to relinquish rights to market the anti-inflammatory drugs in several regions. Under the deal, J&J gained distribution for Remicade and Simponi in Canada, Latin America, the Middle East, Africa, and Asia Pacific. These territories represent about 30% of Merck’s 2010 revenue for the drugs.

The good news for Merck & Co., Inc. (NYSE:MRK) is that diabetes drugs Januvia and Janumet continue to show strong growth. Potential rivals really haven’t mounted a significant threat so far. Eli Lilly & Co. (NYSE:LLY)‘s diabetes drug Tradjenta was approved in 2011 with some thinking that it could rapidly gain market share However, the launch for the drug got off to a relatively sluggish start. Boehringer Ingelheim, Lilly’s partner for Tradjenta, cited an “economic headwind” in Europe and the U.S. that affected sales in 2012.

Most likely to succeed?
While there are several potential roadblocks for sustained stock success, probably the most likely to make a difference in the coming months is a failure in Merck’s pipeline. Another experience like Merck & Co., Inc. (NYSE:MRK) had with Tredaptive could easily stop the stock’s upward trajectory.

In January, the company pulled the plug on the cholesterol drug after Tredaptive failed to reduce heart problems and safety concerns arose in a large-scale clinical study. While the drug was not yet approved in the U.S., it had received approval in around 70 other countries. Merck subsequently pulled Tredaptive from those markets.

It seems unlikely that history would repeat itself with another drug in Merck’s pipeline so soon after this failure, but anything is possible. The company has three drugs under review by the Food and Drug Administration and one under review by European regulators. Any negative news could send Merck & Co., Inc. (NYSE:MRK) stock downward.

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