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Zentalis (ZNTL) Locks In Its Cancer Drug Dose; Jefferies Raises the Target

Zentalis Pharmaceuticals Inc (NASDAQ:ZNTL) is one of the must-buy small cap stocks to buy. On April 10, Jefferies raised its price target on Zentalis Pharmaceuticals Inc (NASDAQ:ZNTL) from $2.50 to $6.00 and left the Hold rating unchanged. This decision came after Zentalis said it had selected the optimal dose of its lead cancer drug azenosertib based on interim data from an ongoing clinical trial.

Zentalis announced in an April 9 press release that it had selected 400mg once daily on a five-days-on, two-days-off schedule as the optimal monotherapy dose of azenosertib for patients with Cyclin E1-positive platinum-resistant ovarian cancer. The company explained that this dose was arrived at after a prespecified interim data analysis from the DENALI Part 2a study.

Zentalis CEO Julie Eastland described the confirmation of azenosertib’s monotherapy dose as a pivotal milestone that puts the company firmly on track toward regulatory approval. She noted that the company is already moving beyond the clinical trials themselves. They are building out its commercial team, expanding manufacturing capacity, and developing the companion diagnostic needed to identify eligible patients.

With dose selection now confirmed, Jefferies is watching two near-term data points that could shift the story further. The first is Phase 2 efficacy data from the full DENALI trial, which Zentalis expects to share by year-end 2026. The second data point is the confirmatory Phase 3 study, ASPENOVA, which is on track to begin enrolling patients in Q2 2026.

Zentalis Pharmaceuticals Inc (NASDAQ:ZNTL) is a clinical-stage biotechnology company. It focuses on developing small-molecule therapies targeting key biological pathways in cancer. Its lead candidate is azenosertib, a WEE1 inhibitor currently in late-stage clinical development for ovarian cancer and other tumor types.

While we acknowledge the risk and potential of ZNTL as an investment, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and doing so within a shorter time frame. If you are looking for an AI stock that is more promising than ZNTL and that has 10,000% upside potential, check out our report about this cheapest AI stock.

READ NEXT: David Abrams’ Hedge Fund Is Betting On These 8 Stocks and 10 Best Energy Storage Stocks to Buy According to Hedge Funds.

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When Jeff Bezos said that one breakthrough technology would shape Amazon’s destiny, even Wall Street’s biggest analysts were caught off guard.

Fast forward a year and Amazon’s new CEO Andy Jassy described generative AI as a “once-in-a-lifetime” technology that is already being used across Amazon to reinvent customer experiences.

At the 8th Future Investment Initiative conference, Elon Musk predicted that by 2040 there would be at least 10 billion humanoid robots, with each priced between $20,000 and $25,000.

Do the math. According to Musk, this technology could be worth $250 trillion by 2040.

Put another way, that’s roughly equal to:

  • 175 Teslas
  • 107 Amazons
  • 140 Metas
  • 84 Googles
  • 65 Microsofts
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  • Bill Gates sees artificial intelligence as the “biggest technological advance in my lifetime,” more transformative than the internet or personal computer, capable of improving healthcare, education, and addressing climate change.
  • Larry Ellison — through Oracle, is spending billions on Nvidia chips and partnering with Cohere to embed generative AI across Oracle’s cloud and apps.
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