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Wedbush Reaffirms Outperform Rating for Tango Therapeutics (TNGX)

Tango Therapeutics Inc. (NASDAQ:TNGX) is one of the 10 most shorted biotech stocks to buy according to hedge funds.

On March 6, Wedbush increased the firm’s price target on Tango Therapeutics Inc. (NASDAQ:TNGX) from $15 to $19 following the company’s fourth quarter financial results and corporate updates. The firm maintained an Outperform rating on the shares, with a price target indicating an upside of more than 12%.

Wedbush noted that vopimetostat, a protein arginine methyltransferase 5 inhibitor, remains on track to enter its first pivotal study in 2026. The planned trial will evaluate the therapy in second-line pancreatic ductal adenocarcinoma.

On February 23, Mizuho initiated coverage of Tango Therapeutics Inc. (NASDAQ:TNGX) with an Outperform rating and $19 price target. The firm believes that the company’s lead precision oncology candidate, vopimetostat, has the potential for “first-in-class and best-in-class” opportunities as monotherapy and in combination with RAS(ON) inhibitors for pancreatic ductal adenocarcinoma and non-small cell lung cancer.

Mizuho estimates that the company could generate $1.8 billion in risk-adjusted worldwide sales of vopimetostat by 2035. It also anticipates positive Phase I data in 2026, which will result in “significant outperformance” of the shares.

Tango Therapeutics Inc. (NASDAQ:TNGX) is a precision oncology company dedicated to finding targeted treatments for cancer patients who currently have limited options. Their pipeline zeroes in on specific genetic vulnerabilities in tumors, with promising therapies in clinical trials targeting tough-to-treat cancers like pancreatic cancer, lung cancer, and glioblastoma.

While we acknowledge the risk and potential of TNGX as an investment, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and doing so within a shorter time frame. If you are looking for an AI stock that is more promising than TNGX and that has 10,000% upside potential, check out our report about this cheapest AI stock.

READ NEXT: 40 Most Popular Stocks Among Hedge Funds Heading Into 2026 and 12 Oversold Financial Stocks to Invest in According to Hedge Funds.

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When Jeff Bezos said that one breakthrough technology would shape Amazon’s destiny, even Wall Street’s biggest analysts were caught off guard.

Fast forward a year and Amazon’s new CEO Andy Jassy described generative AI as a “once-in-a-lifetime” technology that is already being used across Amazon to reinvent customer experiences.

At the 8th Future Investment Initiative conference, Elon Musk predicted that by 2040 there would be at least 10 billion humanoid robots, with each priced between $20,000 and $25,000.

Do the math. According to Musk, this technology could be worth $250 trillion by 2040.

Put another way, that’s roughly equal to:

  • 175 Teslas
  • 107 Amazons
  • 140 Metas
  • 84 Googles
  • 65 Microsofts
  • And 55 Nvidias

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  • Bill Gates sees artificial intelligence as the “biggest technological advance in my lifetime,” more transformative than the internet or personal computer, capable of improving healthcare, education, and addressing climate change.
  • Larry Ellison — through Oracle, is spending billions on Nvidia chips and partnering with Cohere to embed generative AI across Oracle’s cloud and apps.
  • Warren Buffett — not known for tech hype — says this breakthrough could have a ‘hugely beneficial social impact.

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