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Truist Securities Downgrades Harmony Biosciences Holdings, Inc. (HRMY) to Hold After Patent Trial Developments

Harmony Biosciences Holdings, Inc. (NASDAQ:HRMY) is among the 20 Best Investments in 2026.

Harmony Biosciences Holdings, Inc. (NASDAQ:HRMY) is one of the best investment stocks on our list.

TheFly reported on February 20 that Truist Securities downgraded HRMY from Buy to Hold following the conclusion of its bench trial against Paragraph IV filer AET Pharma. The analyst pointed out that Judge Hall’s early post-trial comments raised the possibility of Harmony’s case ending badly. The company consequently voiced concerns over the Wakix franchise, pointing out that there was a high risk and a good chance that generic rivals would join the market before 2029.

On February 17, Harmony Biosciences Holdings, Inc. (NASDAQ:HRMY) announced that the U.S. Food and Drug Administration (FDA) had approved its supplemental New Drug Application for WAKIX (pitolisant) tablets to treat cataplexy in children with narcolepsy who are six years of age or older. Regardless of whether a child has cataplexy or not, Wakix is now the first and only FDA-approved non-scheduled therapy for narcolepsy. This achievement expands the range of therapy options available to patients of all ages by enabling physicians to prescribe WAKIX to patients six years of age and older for excessive daytime sleepiness, cataplexy, or both.

Harmony Biosciences Holdings, Inc. (NASDAQ:HRMY) is a biopharmaceutical company developing therapies for rare neurological disorders, focusing on innovative treatments for conditions like narcolepsy and other sleep-related diseases.

While we acknowledge the potential of HRMY as an investment, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than HRMY and that has a 100x upside potential, check out our report about the cheapest AI stock.

READ NEXT: 12 Unstoppable Dividend Stocks to Buy According to Analysts and Dividend Champions, Contenders and Challengers list: 15 Highest Yielding Stocks.

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The $250 Trillion AI Hype is Real. A few years from now, you’ll probably wish you’d bought this stock.

When Jeff Bezos said that one breakthrough technology would shape Amazon’s destiny, even Wall Street’s biggest analysts were caught off guard.

Fast forward a year and Amazon’s new CEO Andy Jassy described generative AI as a “once-in-a-lifetime” technology that is already being used across Amazon to reinvent customer experiences.

At the 8th Future Investment Initiative conference, Elon Musk predicted that by 2040 there would be at least 10 billion humanoid robots, with each priced between $20,000 and $25,000.

Do the math. According to Musk, this technology could be worth $250 trillion by 2040.

Put another way, that’s roughly equal to:

  • 175 Teslas
  • 107 Amazons
  • 140 Metas
  • 84 Googles
  • 65 Microsofts
  • And 55 Nvidias

And here’s the wild part — this $250 trillion wave isn’t tied to one company, but to an entire ecosystem of AI innovators set to reshape the global economy.

It’s a leap so massive, it could reshape how businesses, governments, and consumers operate worldwide.

Even if that $250 trillion figure sounds ambitious, major firms like PwC and McKinsey still see AI unlocking multi-trillion-dollar potential.

How could anything be worth that much?

The answer lies in a breakthrough so powerful it’s redefining how humanity works, learns, and creates.

And this breakthrough has already set off a frenzy among hedge funds and Wall Street’s top investors.

What most investors don’t realize is that one under-owned company holds the key to this $250 trillion revolution.

In fact, Verge argues this company’s supercheap AI technology should concern rivals.

Before I reveal the details, let’s talk about how some of the richest people on the planet are positioning themselves.

  • Bill Gates sees artificial intelligence as the “biggest technological advance in my lifetime,” more transformative than the internet or personal computer, capable of improving healthcare, education, and addressing climate change.
  • Larry Ellison — through Oracle, is spending billions on Nvidia chips and partnering with Cohere to embed generative AI across Oracle’s cloud and apps.
  • Warren Buffett — not known for tech hype — says this breakthrough could have a ‘hugely beneficial social impact.

When billionaires from Silicon Valley to Wall Street line up behind the same idea — you know it’s worth paying attention to.

Even as we admire what Tesla, Nvidia, Alphabet, and Microsoft have built, we believe an even greater opportunity lies elsewhere…

But the real story isn’t Nvidia — it’s a much smaller company quietly improving the critical technology that makes this entire revolution possible.

And judging by what I’m hearing from both Silicon Valley insiders and Wall Street veterans…

This prediction might not be bold at all:

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