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JPMorgan Raises Cogent Biosciences (COGT) PT to $67 on Sector Model Update

Cogent Biosciences Inc. (NASDAQ:COGT) is one of the best emerging technology stocks to invest in. On December 19, JPMorgan raised the firm’s price target on Cogent Biosciences to $67 from $65 with an Overweight rating on the shares. This sentiment was announced as the firm broadly updated models in its smid-cap biotech group.

In other news, on December 8, Cogent Biosciences announced positive top-line results from the registration-directed APEX Part 2 clinical trial. The study evaluated bezuclastinib, which is a highly selective and potent KIT D816V inhibitor, in 81 patients with advanced systemic mastocytosis/AdvSM, a rare and aggressive blood disorder.  The primary efficacy analysis focused on 68 evaluable patients, demonstrating an Objective Response Rate/ORR of 57% based on modified IWG/mIWG criteria, which account for the reversal of organ damage. When measured by Pure Pathological Response criteria, the ORR reached 80%.

Bezuclastinib was reported to be well-tolerated, with no patients discontinuing the study due to treatment-related adverse events/TRAEs. The most common side effects included hair color change (30.9%), neutropenia (29.6%), and altered taste (28.4%). Dose reductions were infrequent, required by only 14.8% of the participants. These safety results are particularly notable as the drug is designed to avoid the central nervous system and off-target toxicities, such as intracranial bleeding, often seen with other treatments in this class.

This announcement marks the third successful pivotal trial for bezuclastinib in 2025, following the SUMMIT/NonAdvSM and PEAK/GIST trials. Cogent Biosciences expects to submit an NDA to the FDA in H1 2026, with plans for multiple commercial launches in H2 of that year. Detailed data from the APEX trial will be presented at a major medical conference in early 2026.

Cogent Biosciences Inc. (NASDAQ:COGT) is a biotechnology company that develops precision therapies for genetically defined diseases.

While we acknowledge the potential of COGT to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than COGT and that has 100x upside potential, check out our report about this cheapest AI stock.

READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now.

Disclosure: None. This article is originally published at Insider Monkey.

The $250 Trillion AI Hype is Real. A few years from now, you’ll probably wish you’d bought this stock.

When Jeff Bezos said that one breakthrough technology would shape Amazon’s destiny, even Wall Street’s biggest analysts were caught off guard.

Fast forward a year and Amazon’s new CEO Andy Jassy described generative AI as a “once-in-a-lifetime” technology that is already being used across Amazon to reinvent customer experiences.

At the 8th Future Investment Initiative conference, Elon Musk predicted that by 2040 there would be at least 10 billion humanoid robots, with each priced between $20,000 and $25,000.

Do the math. According to Musk, this technology could be worth $250 trillion by 2040.

Put another way, that’s roughly equal to:

  • 175 Teslas
  • 107 Amazons
  • 140 Metas
  • 84 Googles
  • 65 Microsofts
  • And 55 Nvidias

And here’s the wild part — this $250 trillion wave isn’t tied to one company, but to an entire ecosystem of AI innovators set to reshape the global economy.

It’s a leap so massive, it could reshape how businesses, governments, and consumers operate worldwide.

Even if that $250 trillion figure sounds ambitious, major firms like PwC and McKinsey still see AI unlocking multi-trillion-dollar potential.

How could anything be worth that much?

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  • Bill Gates sees artificial intelligence as the “biggest technological advance in my lifetime,” more transformative than the internet or personal computer, capable of improving healthcare, education, and addressing climate change.
  • Larry Ellison — through Oracle, is spending billions on Nvidia chips and partnering with Cohere to embed generative AI across Oracle’s cloud and apps.
  • Warren Buffett — not known for tech hype — says this breakthrough could have a ‘hugely beneficial social impact.

When billionaires from Silicon Valley to Wall Street line up behind the same idea — you know it’s worth paying attention to.

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