Our list highlights the Top 10 Stocks to Buy from Cathie Wood’s Stock Portfolio.
Catherine “Cathie” Wood has been leading the investment management firm ARK Investment Management LLC (“ARK Invest”) as its Founder, CEO, and CIO for nearly 15 years. As per the latest filings, ARK Invest’s Q3 2025 13F portfolio grew to around $16.8 billion from $13.6 billion in Q2. Of the 196 securities in the portfolio, the top 12 accounted for around 50% of the total value, with Tesla being the largest with 8.5% weight. That said, ARK Invest’s investment strategy continues to focus on the leaders, enablers, and beneficiaries of disruptive innovation for the long term.
Under her leadership, the fund’s six actively managed ETFs performed strongly over the three-month and year-to-date periods as of September 30, 2025. For the third quarter of 2025, ARK Autonomous Tech. & Robotics and ARK Innovation ETFs were the best performers with 25.1% and 22.8% price returns, substantially outperforming the MSCI World Index and the S&P 500 Index, which rose 7.3% and 8.1%, respectively.
On a year-to-date basis, all ETFs except the ARK Genomic Revolution ETF registered gains somewhere between 45% and 62%, with the ARK Next Generation Internet ETF leading the pack at 62%, as of the end of September. These gains were again substantially ahead of the broader market indices’ returns, which ranged from 14% to 17%.
READ ALSO: 30 Most Fantastic Stocks Every Investor Should Pay Attention To and 10 Hottest Smid-Cap Stocks So Far In 2025.
In ARK Invest’s market update on November 14, Cathie Wood explained that recent market volatility stems from three factors: a temporary liquidity squeeze tied to delayed quantitative tightening, treasury cash buildup during the government shutdown, and uncertainty about the next rate cut. While she said inflation is easing, she also noted that the job market is softening and that technological shifts are contributing to deflation.
Wood also rejected the idea that an AI bubble is forming, saying today’s advances are delivering tangible benefits and that businesses are only starting to adapt. She expects the broader impact of these technologies to drive stronger economic growth over time. She stated:
“The seeds that were planted in the 20 years that ended in the tech and telecom bubble have been germinating for the last 25 to 30 years. Back then, the technologies were not ready. The costs were way too high. We didn’t get the cloud until 2006. We didn’t get the first real breakthrough in AI until 2012 (deep learning), and then the even bigger breakthrough in 2017 that was transformer architecture. And of course, we had the ChatGPT moment in late 2022. We think the AI story has just begun.”
With that background, let’s explore the top 10 stocks to buy from Cathie Wood’s stock portfolio.
Our Methodology
To identify the top stocks from Cathie Wood’s portfolio, we began by reviewing ARK Investment Management’s Q3 2025 13F portfolio using Insider Monkey’s 13F database. We then shortlisted and ranked the top 10 equity holdings by portfolio weight in ascending order. Additionally, we included data on hedge fund holdings in these companies, based on Q3 2025 data from Insider Monkey’s database, to provide further insight into investor interest.
We have also added the performance of each stock from the end of Q3 2025 through November 28 to provide readers with insight into how Cathie Wood’s portfolio picks have played out in that period.
Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 427.7% since May 2014, beating its benchmark by 264 percentage points (see more details here).
Note: All pricing data is as of market close on November 28, 2025. All comparisons of portfolio allocation changes in ARK’s 13F portfolio reflect changes versus Q2 2025, unless stated otherwise.
Cathie Wood’s Stock Portfolio: Top 10 Stocks to Buy
10. Advanced Micro Devices Inc. (NASDAQ:AMD)
Portfolio Weight: 2.9%
Value of Position: $495 Million
Share Price Return (Sep 30—Nov 28): 34.5%
Number of Hedge Fund Holders: 115
Advanced Micro Devices Inc. (NASDAQ:AMD) is among the top 10 stocks to buy from Cathie Wood’s stock portfolio. With a value of approximately $495 million, the company accounts for about 3% of Cathie Wood-led ARK Investment Management’s 13F portfolio as of the end of September. During the third quarter, ARK increased its AMD position by roughly 13%, rising from 2.71 million to 3.06 million shares.
On November 20, Simon Leopold, an analyst from Raymond James, resumed coverage of Advanced Micro Devices Inc. (NASDAQ:AMD) with an Outperform rating and a price target of $377. This update was part of the analyst’s resumption of coverage of seven leading semiconductor companies, including Nvidia, Marvell, Broadcom, ARM, Astera Labs, and Intel.
Leopold appeared quite upbeat about these companies, believing that generative artificial intelligence has “transformed a typically cyclical market sector of semiconductors into a secular boom.” Moreover, he believes that semiconductors are proving to be the concrete base for “an unprecedented structural shift in the technology landscape.”
The analyst also considers Advanced Micro Devices Inc. (NASDAQ:AMD) “best positioned to compete with NVIDIA” in merchant GPUs. On his investment thesis, Leopold further elaborated:
“Investor skepticism lingers, but shares have attracted a broader audience than in the past and have delivered outstanding performance YTD… Fundamentals need to catch up, and we believe they will. The newest wins with OpenAI and HUMAIN for ~1 GW could be worth $15B in 2026. These grow to over 2 GW in 2027. AMD appears poised for continued server and PC share gains, too. Additionally, the OpenAI deployment may serve as an important endorsement for potentially encouraging other model builders and hyperscalers to adopt AMD GPUs. The AI TAM is large enough to support multiple chip suppliers, and AMD will be among the participants.”
Advanced Micro Devices Inc. (NASDAQ:AMD) is a leading semiconductor company specializing in high-performance computing and graphics solutions. Its broad product portfolio includes microprocessors, graphics processors, and system-on-chip (SoC) solutions designed for data centers, gaming, and embedded systems.
9. Tempus AI Inc. (NASDAQ:TEM)
Portfolio Weight: 3.5%
Value of Position: $579 Million
Share Price Return (Sep 30—Nov 28): -3.4%
Number of Hedge Fund Holders: 32
Tempus AI Inc. (NASDAQ:TEM) is among the top 10 stocks to buy from Cathie Wood’s stock portfolio. As of the end of September 2025, Tempus holds the ninth largest position in Cathie Wood’s ARK Investment Management’s 13F portfolio with $579 million (or 3.45% of the portfolio).
On Tuesday, November 25, BTIG’s Mark Massaro reiterated his Buy rating on Tempus AI Inc. (NASDAQ:TEM) and increased the price target from $96 to $105. His decision followed his recent discussions with the company’s management. In his note, the analyst highlighted several long-term growth drivers that underpin the company’s investment case.
First among them was management’s emphasis on the durability and diversification of Tempus AI Inc.’s (NASDAQ:TEM) data and pharma business. In addition, Ambry Genetics is outperforming the firm’s estimates and is now expected to post over 20% growth, supported by expanding demand in hereditary and rare disease testing.
Another factor, according to Massaro, is Tempus’s advanced algorithm solutions business, which he views as an underappreciated asset. As per his analysis, over time, this segment could deliver gross margins exceeding 80%, further bolstering the company’s growth.
Earlier, on November 11, an analyst at Morgan Stanley had also raised his price target from $68 to $80, while keeping his Buy rating intact.
Tempus, which went public on June 14, 2024, is a health technology company. It aims to advance precision medicine through the practical application of artificial intelligence, including generative AI, in healthcare to create intelligent diagnostics.
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