In this piece, we will discuss Bill Gates’s Stock Portfolio: Top 15 Stock Picks.

Bill Gates’s disciplined and long-term investment philosophy is reflected in the investment strategy of the Bill & Melinda Gates Foundation Trust, which manages the endowment supporting one of the world’s largest philanthropic organizations. Overseen by Chief Investment Officer Michael Larson since 1994, the trust boasts over $47.7 billion in investments, according to the Q2 2025 13F filing. The fund’s portfolio, highly concentrated in stable, blue-chip stocks, is led by Microsoft, Berkshire Hathaway, and Waste Management Inc.. The three leading stocks account for 27.27%, 24.53%, and 15.44% of total holdings, respectively. Representing over half of the portfolio, these three top positions reflect the trust’s focus on quality, resilience, and sustainable returns.

Meanwhile, Bill Gates appeared in an interview with CNBC on October 28, where he shared his broader outlook on the AI boom. He compared AI’s rise to the early internet era, which initially featured hype and speculation but ultimately led to lasting innovation. He highlighted the technology’s massive long-term potential in several areas, including healthcare, education, and science. At the same time, he noted that this boom will feature many ventures that may fail. Thus, he expressed balanced optimism toward AI while acknowledging its societal and infrastructural challenges. This stance reflects his thoughtful approach, which is rooted in innovation, sustainability, and long-term value creation.

With this background in mind, let’s jump to the top 15 stock picks in Bill Gates’s stock portfolio.

Our Methodology

To curate the list of the top 15 stock picks from Bill Gates’s stock portfolio, we scanned The Bill & Melinda Gates Foundation Trust’s holdings using its 13F filings for the second quarter of 2025. We ranked the stocks based on the value of the trust’s holdings in each stock as of the end of the quarter. Furthermore, we considered the hedge fund sentiment surrounding each stock, using Insider Monkey’s hedge fund database, which tracks over 1,000 hedge funds. The list of top 15 stock picks from Bill Gates’s stock portfolio is presented in ascending order based on Bill Gates’s stake.

We have added the performance of each stock from the end of Q2 2025 to November 3, providing readers with insight into how Bill Gates’s portfolio picks have played out during this period.

Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 427.7% since May 2014, beating its benchmark by 264 percentage points (see more details here).

Bill Gates’s Stock Portfolio: Top 15 Stock Picks

15. Madison Square Garden Sports Corp. (NYSE:MSGS)

Bill Gates’s Stake: $123,783,234

Number of Hedge Fund Holders: 50

Share Price Return Between July 1 and November 3: 5.82%

Representing 0.26% of Bill Gates’s stock portfolio, Madison Square Garden Sports Corp. (NYSE:MSGS) is one of his top 15 stock picks.

Madison Square Garden Sports Corp. (NYSE:MSGS) announced results for Q1 fiscal 2026 on October 31, 2025.

Off to a challenging start to fiscal 2026, Madison Square Garden Sports Corp. (NYSE:MSGS) reported $39.5 million in revenue, a 26% year-over-year decrease. The decline was led by an $11.4 million drop in league distributions, alongside a $2.3 million decrease in local media rights fees following amendments to the Knicks’ and Rangers’ agreements with MSG Networks, a regional cable and satellite television network.

Weaker top-line results and higher administrative expenses resulted in an adjusted operating loss of $20.8 million, which was $18.5 million worse than the loss reported in the same period last year. Driven by increased lease, employee, and service-related expenses, Madison Square Garden Sports Corp. (NYSE:MSGS)’s selling, general, and administrative costs increased by 10% to $57.8 million. The company reported diluted loss per common share of $0.37.

While acknowledging short-term financial pressures, Madison Square Garden Sports Corp. (NYSE:MSGS)’s CEO James L. Dolan emphasized the continued strong demand for the Knicks and Rangers. His commentary also reflected confidence in the long-term value of MSG Sports’ premier franchises and its potential to create value for shareholders in the long term.

Madison Square Garden Sports Corp. (NYSE: MSGS) is focused on owning and operating professional sports franchises, including the New York Knicks (NBA) and the New York Rangers (NHL). It also owns and operates development league teams, alongside training facilities.

14. Schrödinger, Inc. (NASDAQ:SDGR)

Bill Gates’s Stake: $140,471,080

Number of Hedge Fund Holders: 25

Share Price Return Between July 1 and November 3: -0.29%

Schrödinger, Inc. (NASDAQ:SDGR), which accounts for 0.29% of Bill Gates’s stock portfolio, is one of his top 15 stock picks.

Schrödinger, Inc. (NASDAQ:SDGR) and Copernic Catalysts announced on October 30, 2025, that they have surpassed the final technical milestone for Neptune, their jointly developed ammonia synthesis catalyst.

The breakthrough catalyst, designed to operate under milder conditions, achieved more than twice the ammonia yield of other similar technologies under real-world reactor conditions. Furthermore, industrial ammonia plant capacity could be boosted by up to 47%, potentially generating $110 million in annual profits per plant and reducing energy consumption by 23%. Following this achievement, Schrödinger, Inc. (NASDAQ:SDGR), alongside Copernic, plans to collaborate on a selective ethylene oxide catalyst. With this, they aim to reduce emissions and improve yield in large-scale chemical production.

Meanwhile, on October 8, 2025, KeyBanc reiterated its “Overweight” rating on Schrödinger, Inc., but reduced its price target from $30 to $28, according to The Fly. While noting mixed trends in healthcare IT spending, the investment firm expressed confidence in platforms demonstrating strong ROI, an aspect that is clearly reflected in the company’s computational tools.

Schrödinger, Inc. (NASDAQ:SDGR) accelerates molecular discovery for the life sciences and materials science industries by developing physics-based computational software.

13. Crown Castle Inc. (NYSE:CCI)

Bill Gates’s Stake: $145,883,997

Number of Hedge Fund Holders: 49

Share Price Return Between July 1 and November 3: -13.69%

Representing 0.31% of Bill Gates’s stock portfolio, Crown Castle Inc. (NYSE:CCI) is one of his top 15 stock picks.

On October 23, 2025, BMO Capital’s Ari Klein reiterated his “Buy” rating on Crown Castle Inc. (NYSE:CCI) with a $114 price target. Alongside the company’s strong performance in the third quarter, the analyst cited the company’s strategic execution, margin expansion potential, and transition to a U.S. tower pure-play as key growth drivers. The analyst also highlighted the raised 2025 guidance, which reflects confidence in continued revenue growth and margin expansion.

In its earnings release announced the day before, Crown Castle Inc. (NYSE:CCI) reported $323 million in net income, which is an increase from $303 million in the previous year. This comes despite the 5.1% decline in site rental revenue due to Sprint cancellations and amortization impacts. Meanwhile, $718 million was reported in adjusted EBITDA, alongside AFFO per share of $1.12. The 2025 guidance featured higher straight-line revenues, lower operating costs, and reduced interest expenses, driving expectations for increased profitability.

Crown Castle Inc. (NYSE:CCI) is focused on owning, operating, and leasing approximately 40,000 cell towers and 90,000 route miles of fiber, supporting small cells and broadband connectivity across the U.S.