Ten stocks kicked off the trading week with double-digit gains, four of which soared to new all-time highs, as investor sentiment was bolstered by a flurry of dealmaking activities.

The firms were dominated by companies benefitting largely from the booming artificial intelligence sector, as technology giants continued to pour billions into advancing the sector, spilling over to their stocks.

Meanwhile, Wall Street finished mixed, with the Nasdaq and the S&P 500 the only gainers, up by 0.71 percent and 0.36 percent, respectively. The Dow Jones ended down by 0.14 percent.

This article highlights the 10 big names that performed well in Monday’s trading session, alongside the reasons behind their gains.

To come up with the list, we focused exclusively on mid-cap stocks with more than $2 billion in market capitalization and 5 million shares in trading volume.

10. Bitmine Immersion Technologies Inc. (NYSEAmerican:BMNR)

Shares of Bitmine Immersion rallied for a fourth straight day on Monday, jumping 11.38 percent to close at $63.10 apiece following news that it has raised its ownership in Ethereum tokens to a total of $13.4 billion.

In a statement, Bitmine Immersion Technologies Inc. (NYSEAmerican:BMNR) said it now holds more than 2.8 million units of Ethereum carrying an average price of $4,535, as compared with the token’s price of $4,697 as of writing, marking unrealized gains of over $458 million.

Bitmine Immersion Technologies Inc. (NYSEAmerican:BMNR) remains the token’s largest treasury holder to date.

“We continue to believe Ethereum is one of the biggest macro trades over the next 10-15 years. Wall Street and AI moving onto the blockchain should lead to a greater transformation of today’s financial system. And the majority of this is taking place on Ethereum,” said Bitmine Immersion Technologies Inc. (NYSEAmerican:BMNR) Chairman Thomas Lee.

Apart from Ethereum, it also owns 192 Bitcoins, as well as indirect ownership in WorldCoins through a recent $113 million investment in Eightco Holdings Inc. (NASDAQ:ORBS).

9. UiPath Inc. (NYSE:PATH)

UiPath extended its rally to a second day on Monday, jumping 12.56 percent to close at $14.52 apiece, mimicking the surge in artificial intelligence stocks on growing investor optimism and a flurry of developments in the industry.

Monday also saw its share price at a 10-month high, just 71 cents shy of its 52-week price of $15.93.

Investor optimism was further supported by UiPath Inc.’s (NYSE:PATH) announcement last week that it partnered with technology giant Nvidia Corp. to support enterprise customers in fortifying their existing automated workflows with AI capabilities in high-trust scenarios, such as fraud detection or care management in healthcare.

A key aspect in the partnership was the introduction of an integration service connector that would connect UiPath Inc. (NYSE:PATH) and Nvidia’s NIM and Nemotron, enabling enterprises to seamlessly and rapidly integrate generative AI features into their applications.

Additionally, UiPath Inc. (NYSE:PATH) said it was exploring opportunities across agentic automation in areas including advancing agentic orchestration and developing differentiated agents, among others.

“Sensitive processes like fraud detection or healthcare workflows demand AI that is both powerful and trustworthy. By integrating NVIDIA NIM models directly into the UiPath Platform, customers can deploy and orchestrate their own hosted models with enterprise-grade governance. That means they can bring AI into their most critical processes with the control, transparency, and confidence they need to deliver real business impact,” said UiPath Inc. (NYSE:PATH) Chief Product Officer Graham Sheldon.

8. Comerica Inc. (NYSE:CMA)

Comerica extended its rally to a fourth straight day on Monday to hit a new all-time high as investors gobbled up shares following news that it was being acquired by Fifth Third Bancorp for $10.9 billion.

During the session, Comerica Inc. (NYSE:CMA) shares propelled to a record high of $83.22 before paring gains to finish the day at $80.20.

In a joint statement, Comerica Inc. (NYSE:CMA) and Fifth Third said they will merge in an all-stock transaction, under which CMA shareholders will be able to receive 1.8663 shares in Fifth Third, representing $82.88 per share and a 20-percent premium to CMA’s 10-day volume-weighted average stock price.

The transaction is expected to create the 9th largest bank in the US with approximately $288 billion in assets.

At close, Fifth Third shareholders will own approximately 73 percent, and Comerica Inc. (NYSE:CMA) shareholders will own approximately 27 percent of the combined company.

In terms of leadership, Comerica Inc. (NYSE:CMA) said its chairman, president, and CEO, Curtis Farmer, would join the combined company as vice chairman. He will also join the board of directors upon retirement.

The transaction is expected to close in the first quarter of 2026, subject to regulatory approvals.

7. IREN Ltd. (NASDAQ:IREN)

IREN Ltd. soared to a new all-time high on Monday, as investor funds poured into artificial intelligence stocks following aggressive dealmaking activities in the industry.

In intra-day trading, IREN Ltd. (NASDAQ:IREN) hit a new record high of $58.28 before trimming gains to finish the day just up by 14.45 percent at $57.75 apiece, supported by OpenAI’s newly clinched supply deal with Advanced Micro Devices Inc. (AMD).

In a statement, AMD said it entered into a definitive agreement with OpenAI to supply the latter with 6 gigawatts of Instinct GPUs to enable an ambitious AI buildout and advance the entire ecosystem. The first GW is expected to be deployed in the second half of 2026.

As a pioneer in the AI industry, OpenAI’s ongoing expansion program bolstered optimism for companies riding the wave, including IREN Ltd. (NASDAQ:IREN), a Bitcoin miner slowly transitioning to AI servicing through expanding its cloud business to support demand growth in high-performance computing (HPC) services.

Amid the developments, IREN Ltd. (NASDAQ:IREN) earned an “overweight” rating and a $75 price target from investment firm Bernstein—a 275 percent increase from its previous target of $20.

The upgrade was based on IREN Ltd.’s (NASDAQ:IREN) differentiated approach among Bitcoin miners, underscoring the development of its own AI infrastructure, while competitors pursue capital-light co-location deals with AI cloud companies.

6. Opendoor Technologies Inc. (NASDAQ:OPEN)

Shares of Opendoor Technologies jumped by 14.43 percent on Monday to end at $9.28 apiece after hinting at accepting cryptocurrency payments for home sales, marking its foray into said assets.

Over the weekend, Opendoor Technologies Inc. (NASDAQ:OPEN) Chief Executive Officer Kaz Nejatian responded to a social media user who suggested the use of cryptocurrencies for real estate buying on the platform, saying that “we will. [We] just need to prioritize it.” He did not elaborate on the timeline and the specific cryptocurrencies to be accepted.

The confirmation became a boost to Opendoor Technologies Inc. (NASDAQ:OPEN), which is underway with the implementation of strategic initiatives towards a turnaround and revival, which included the potential layoff of the majority of its total workforce.

In a recent interview, Opendoor Technologies Inc. (NASDAQ:OPEN) Chairman Keith Rabois vowed to slash the company’s workforce by 85 percent, which could affect some 1,190 employees.

“There [are] 1,400 employees at Opendoor. I don’t know what most of them do. We don’t need more than 200 of them,” he was quoted as saying.

5. Archer Aviation Inc. (NYSE:ACHR)

Archer Aviation extended its winning streak to a fourth straight day on Monday to be just 11 cents shy of its 52-week high, as investors snapped up on developments in the electric vertical take-off and landing (eVTOL) industry amid speculations that Tesla Inc. may soon join the sector.

During the session, Archer Aviation Inc. (NYSE:ACHR) soared to a five-month high of $13.81 before trimming gains to end the day just up by 17.89 percent at 413.64 apiece, purely due to social media buzz that the Elon Musk-led firm was officially making foray into the eVTOL sector, following a short video on social media that showed a rolling turbine with its logo in it.

The video ended with the numbers “10/7,” which many interpreted as October 7, the potential launch date.

Meanwhile, the rally on Archer Aviation Inc. (NYSE:ACHR) was due to investor expectations for a potential partnership with Tesla, although the company declined media requests for confirmation.

In other news, Archer Aviation Inc. (NYSE:ACHR) recently announced a new $500 million aircraft order from Soracle Corporation—a joint venture company between Japan Airlines and Sumitomo Corp.—to bring advanced air mobility (AAM) services to Japan.

The investment covers the purchase of 100 Midnight aircraft in line with plans to offer an alternative mode of transportation in congested cities in Japan, such as Tokyo, Osaka, Nagoya, Hokkaido, Setouchi, and Okinawa.

4. NANO Nuclear Energy Inc. (NASDAQ:NNE)

NANO Nuclear extended its rally to a fourth consecutive session to hit a new all-time high on Monday, as investors poured funds into stocks that would benefit from the booming artificial intelligence industry, including the nuclear energy sector.

During the session, NANO Nuclear Energy Inc. (NASDAQ:NNE) soared to its highest price of $56.46 before paring gains to end the day just up by 20.54 percent at $53.63 apiece.

NANO Nuclear Energy Inc. (NASDAQ:NNE) joined the rally in energy stocks after a series of dealmaking activities to advance AI, the latest being OpenAI’s supply deal with Advanced Micro Devices.

AI deals have recently become the largest catalyst for the nuclear energy sector, with the ongoing developments and aggressive expansion across the sector potentially translating to energy demand growth amid the power-hungry data centers.

In other news, NANO Nuclear Energy Inc. (NASDAQ:NNE) was recently added to the S&P Global Broader Market Index (BMI)—the world’s first float-adjusted global benchmark. Its inclusion paved the way for more public exposure, as funds and investment firms tracking the latter would need to add its stock into their fund portfolios to reflect the index’s composition.

The S&P Global BMI is designed to capture the global, investable equity universe, spanning 48 developed and emerging market countries and representing over 99 percent of available market capitalization worldwide.

3. Applied Optoelectronics, Inc. (NASDAQ:AAOI)

Applied Optoelectronics soared by 20.98 percent on Monday to finish at $33.79 apiece, tracking the overall optimism for the artificial intelligence sector, thanks to a flurry of dealmaking developments in the industry.

Applied Optoelectronics, Inc. (NASDAQ:AAOI), a leading developer of advanced optical products, including those used in modern data centers, stands to benefit from the booming AI growth as more technology giants continue to invest billions of dollars to advance the sector.

In other news, Applied Optoelectronics, Inc. (NASDAQ:AAOI) showcased its 100G VCSEL technology with the demonstration of an 800G OSFP 2xSR4 multimode optical transceiver at the recently concluded ECOC 2025 in Copenhagen, Denmark.

Applied Optoelectronics, Inc. (NASDAQ:AAOI) said its vertically integrated design and manufacturing capabilities enable the production of 100G VCSELs at 850nm—the industry’s preferred solution for short-reach connections under 100 meters in hyperscale data centers and AI and machine-learning clusters.

“By leveraging these VCSELs in its 800G OSFP 2xSR4, AOI delivers a cost-efficient, low-power optical solution designed for the next generation of short-reach multimode links,” it said.

2. Advanced Micro Devices Inc. (NASDAQ:AMD)

Advanced Micro propelled to a new all-time high on Monday, as investors cheered a chip supply deal with OpenAI, which could deliver the former billion-dollar revenues and lure a 10-percent investment from the latter.

In a statement, Advanced Micro Devices Inc. (NASDAQ:AMD) said it inked a definitive agreement with OpenAI for the supply of 6 GW of AI infrastructure to enable large-scale AI deployments and advance the entire ecosystem.

The first gigawatt is expected to be delivered in the second half of 2026.

“Our partnership with OpenAI is expected to deliver tens of billions of dollars in revenue for AMD while accelerating OpenAI’s AI infrastructure buildout,” said Advanced Micro Devices Inc. (NASDAQ:AMD) Chief Finance Officer Jean Hu.

“This agreement creates significant strategic alignment and shareholder value for both AMD and OpenAI and is expected to be highly accretive to AMD’s non-GAAP earnings-per-share,” she added.

As part of the agreement, Advanced Micro Devices Inc. (NASDAQ:AMD) has issued a warrant to OpenAI for an option to acquire 160 million AMD shares, structured to vest as specific milestones are achieved, including the first GW delivery.

1. Eightco Holdings Inc. (NASDAQ:ORBS)

Eightco rocketed by 34.34 percent on Monday to close at $11.07 apiece as investors poured funds into its stock, after Bitmine Immersion—the largest Ethereum treasury holder in the world—posted strong optimism for the cryptocurrency asset, believing that it would be one of the biggest macro trades over the next 10 to 15 years.

The comment propelled shares in Eightco Holdings Inc. (NASDAQ:ORBS), which announced earlier last month that it would make Ethereum its secondary reserve asset after Worldcoin.

As of writing, Ethereum prices were up by 3.93 percent at $4,692 each.

Additionally, Eightco Holdings Inc.’s (NASDAQ:ORBS) rally was supported by Bitmine’s aggressive expansion into Ethereum, having raised its ownership in the latter anew to $13.4 billion.

It is worth noting that Bitcoin last month also invested $113 million in Eightco Holdings Inc. (NASDAQ:ORBS) as it aims to capitalize on the growing Worldcoin adoption, the latter’s major cryptocurrency reserve.

Apart from Bitmine, Eightco Holdings Inc. (NASDAQ:ORBS) also earned the support of institutional investors, namely World Foundation, Discovery Capital Management, GAMA, FalconX, Kraken, Pantera, GSR, Coinfund, Occam Crest, Diametric, and Brevan Howard, after securing financial backing from the said firms.

While we acknowledge the potential of ORBS to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than ORBS and that has 100x upside potential, check out our report about this cheapest AI stock.

READ NEXT: 20 Best AI Stocks To Buy Now and 30 Best Stocks to Buy Now According to Billionaires.

Disclosure: None. Insider Monkey focuses on uncovering the best investment ideas of hedge funds and insiders. Please subscribe to our free daily e-newsletter to get the latest investment ideas from hedge funds’ investor letters by entering your email below.