In this article, we will look at the 10 Most Profitable Stocks to Buy Now.

​On November 17, Jeremy Siegel, former Wharton professor and WisdomTree chief economist, appeared on a CNBC Television interview to discuss the AI valuations. Siegel noted that the market is currently trading at around 23 times forward earnings. However, he highlighted that excluding the AI/Mag 7 stocks, the market is trading at around 20 times forward earnings. Sigel noted that, considering the interest rates, liquidity, and other macroeconomic factors, 20 times earnings is the right valuation ratio. He added that this brings the discussion to a pertinent question regarding the valuations of AI being too high.

​Sigel believes that AI is a revolution, which is unlike anything we have seen in our lifetimes, and holds the potential to transform the economy of the United States. He highlighted that the biggest risk of AI investment is not regarding the effectiveness of AI, but about the same work being done much more cheaply. Sigel drew a comparison with the dotcom era to support his argument. He noted that during the dotcom era, internet companies invested heavily in laying cables around the world only to find out that a thousand times more data could have been transmitted through fiber optics, which later led to the dotcom bust. Therefore, Sigel concludes that while there are no doubts about the effectiveness of the AI investment, the concerns regarding whether it requires trillions of dollars are valid.

​With that, let’s take a look at the 10 Most Profitable Stocks to Buy Now.

​Our Methodology

To compile the list of 10 Most Profitable Stocks to Buy Now, we used the Stock Analysis stock screener, WSJ, and Insider Monkey’s Q2 2025 database. Using the screener, we aggregated a list of the top 30 US-listed stocks by market cap. Out of these stocks, we shortlisted the ones with more than $15 billion in net income (TTM) and more than 15% net profit margins (TTM). Lastly, we ranked these companies in ascending order of the net income (TTM). We have also added the hedge fund sentiment around each stock sourced from Insider Monkey’s database.

​​​Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 427.7% since May 2014, beating its benchmark by 264 percentage points (see more details here).

​10 Most Profitable Stocks to Buy Now

​10. Wells Fargo & Company (NYSE:WFC)

Net Income (TTM): $19.72 billion

Net Profit Margins (TTM): 15.62%

Number of Hedge Fund Holders: 75

​Wells Fargo & Company (NYSE:WFC) is one of the Most Profitable Stocks to Buy Now. On November 12, John McDonald CFA from Truist Financial reiterated a Buy rating on Wells Fargo & Company (NYSE:WFC) without disclosing any price target. Earlier on November 3, Jason Goldberg from Barclays had also reiterated a Buy rating on the stock with a price target of $94.

​The reiterated bullish sentiment on the stock follows the company’s release of fiscal Q3 2025 results, announced on October 14. The company reported 5.25% year-over-year revenue growth to $21.44 billion, surpassing estimates by 272.33 million. Moreover, the EPS of $1.73 also topped estimates by $0.19. Management attributed revenue growth to higher net interest income, along with strong growth in fee-based income from consumer and commercial businesses.

​In addition, on November 6, Wells Fargo & Company (NYSE:WFC) also presented at the BancAnalysts Association of Boston Conference, where CFO Mike Santomassimo outlined strategic initiatives. He noted that the bank aims for best-in-class returns across all business segments. Moreover, the bank also aims for a CET1 ratio of 10%-10.5%, which stood at 11% during Q3 2025. Santomassimo highlighted that the bank has achieved $15 billion in gross savings over the past 5 years, which has helped the company increase its spending for the betterment of the company.

​Wells Fargo & Company (NYSE:WFC) is a large financial services company offering banking, mortgage, and investment products.

​9. Visa Inc. (NYSE:V)

Net Income (TTM): $19.85 billion

Net Profit Margins (TTM): 49.63%

Number of Hedge Fund Holders: 167

​Visa Inc. (NYSE:V) is one of the Most Profitable Stocks to Buy Now. On November 12, Visa Inc. (NYSE:V) announced a breakthrough pilot at Web Summit that allows businesses and platforms to send out payouts directly to recipients’ stable coin wallets.

​The pilot allows creators and gig workers a faster way to access funds by bypassing traditional banking delays. Moreover, businesses using Visa Direct can fund payouts in fiat currency, while recipients can opt to receive funds in stable coins, specifically USD-backed stable coins like USDC. The program is currently in the onboarding stage with select partners; Visa Inc. (NYSE:V) expects wider access in 2026.

​In addition, Wall Street remains bullish on the stock since the fiscal Q4 2025 earnings release. Earlier on November 10, Harshita Rawat from Bernstein reiterated a Buy rating on the stock with a price target of $418.

Visa Inc. (NYSE:V) announced results on October 28, with revenue growing 11.51% year-over-year to $10.72 billion, surpassing estimates by $105.86 million. Moreover, the EPS of $2.98 also surpassed estimates by $0.01. Management attributed growth to a 9% year-over-year increase in global payment volume and 11% growth in cross-border volume.

​Visa Inc. (NYSE:V) is an international payment technology company that enables secure and fast money movement and commerce across more than 200 countries.