Ten companies soared by double- and triple-digits last week, outperforming Wall Street’s three major indices, thanks to a broader investor optimism and company-specific developments that sparked buying appetite.

Meanwhile, the Dow Jones dipped by 15 percent week-on-week; the S&P 500 decreased by 0.31 percent; and the tech-heavy Nasdaq dropped by 0.65 percent.

In this article, we focus on the 10 stocks that led last week’s performance to help you decide whether it is time to take profits or continue loading portfolios.

To come up with the list, we focused exclusively on mid-cap stocks with more than $2 billion in market capitalization and 5 million shares in trading volume.

The stocks were chosen based on their gains between September 19 and 26, 2025.

10. First Majestic Silver Corp. (NYSE:AG)

First Majestic Silver Corp. (NYSE:AG) grew by 14.3 percent week-on-week, as investors poured funds into mining companies after the latest US inflation rate figures solidified hopes for more interest rate cuts.

On Friday, the Commerce Department announced that the personal consumption expenditures index posted a 0.3 percent gain in August, bringing the annual headline inflation rate to 2.7 percent.

Headline inflation rate grew slightly from 2.6 percent in July, but remained within economists’ expectations of 2.8 percent.

The latest figures strengthened hopes that the US central bank would continue lowering rates toward the end of the year, sparking rosy prospects for precious metals like silver and gold.

Lower interest rates tend to weaken the US dollar, making gold and silver much cheaper to foreign investors.

Amid optimism, First Majestic Silver Corp. (NYSE:AG) also hit its highest 52-week price of $12.67 before slight profit-taking persisted toward the end of the week.

9. Endeavour Silver Corp. (NYSE:EXK)

Endeavour Silver jumped by 15.38 percent week-on-week to hit a new all-time high as investor funds shifted to mining companies following the metal’s rally to a fresh 14-year record.

During the week, Endeavour Silver Corp. (NYSE:EXK) touched its highest 52-week price of $8.21 before trimming gains to end Friday’s trading at $7.80 apiece.

Last week, the spot prices of silver grew to $46, its highest level in 14 years, as investors turned optimistic that the US central bank would implement more interest rate cuts by the end of the year.

Lower rates typically benefit precious metals like silver and gold, as interest rate cuts tend to weaken the US dollar, making the dollar-denominated metals much cheaper to foreign investors.

Endeavour Silver Corp. (NYSE:EXK) is one of the listed mining firms based in Canada, focusing on silver production. In the first six months of the year, it was able to produce 1.48 million ounces of silver and 7,755 ounces of gold for 2.5 million ounces of silver equivalent.

It also realized $85.3 million from the sale of 1.45 million oz of silver and 7,706 oz of gold, leading to a 46 percent increase in revenues from operations as compared with the same period last year.

8. Perpetua Resources Corp. (NASDAQ:PPTA)

Shares of Perpetua Resources soared by 15.56 percent week-on-week to hit a new record high as investor sentiment was boosted by a partnership with four firms to ramp up the supply of a critical mineral for the production of bullets and solar panels, among others.

Last Friday, Perpetua Resources Corp. (NASDAQ:PPTA) jumped to its highest 52-week price of $22.62 before paring gains to finish the day just up by 11.37 percent at $21.16 apiece.

According to a report by Reuters, quoting Perpetua Resources Corp. (NASDAQ:PPTA) CEO Jon Cherry, the company is in talks with Glencore, Trafigura, Clarios, and Sunshine Silver for the refinement of antimony to boost Western supplies of the mineral, which China has blocked exports of.

This followed the green light of the US government a few days earlier for the construction of its antimony and gold mine in Idaho. The site is poised to be the largest antimony supplier in the US.

“We are encouraged by emerging opportunities to expand domestic mineral processing capacity in America and intend to make well-informed, market-based decisions when selecting a partner,” Cherry was quoted as saying.

7. Crescent Energy Company (NYSE:CRGY)

Crescent Energy grew its share prices by 16.17 percent week-on-week as investors poured funds into oil and gas companies amid growing tensions between Russia and Ukraine that raised expectations for supply cuts and higher prices.

On Friday, prices of Brent crude grew by 1.02 percent to $70.13 per barrel, while the West Texas Intermediate jumped by 1.14 percent to $65.72 after Ukraine attacked Russia’s energy infrastructure, cutting the country’s fuel exports.

Crescent Energy Company (NYSE:CRGY) jumped alongside its counterparts following the news.

In other developments, Crescent Energy Company (NYSE:CRGY) is targeting to close its planned $3.1 billion merger with Vital Energy by the end of the year.

Last month, Crescent Energy Company (NYSE:CRGY) announced that it entered into a definitive agreement to merge with Vital Energy, Inc. (NYSE:VTLE) for an all-stock transaction, inclusive of its net debt.

Under the terms, VTLE shareholders will receive an equivalent of 1.9062 CRGY common shares for every stock they own.

6. Sibanye Stillwater Limited (NYSE:SBSW)

Sibanye saw its share prices surge by 16.98 percent week-on-week to hit a fresh record high as investors loaded portfolios amid higher prices of platinum and gold.

On Friday alone, Sibanye Stillwater Limited (NYSE:SBSW) climbed to a 52-week high of $11.25 before trimming gains to end the day just up by 4.69 percent at $11.16 apiece, after spot prices of gold and platinum surged by 0.28 percent and 3.37 percent, respectively.

As of writing, the latest data from Bloomberg showed that spot prices of gold were at $3,759.98 while prices of platinum finished at $1,580.56 per troy ounce.

Meanwhile, higher prices of gold were buoyed by hopes for more interest rate cuts, after the headline inflation rate settled within economists’ expectations.

Lower rates tend to weaken the US dollar, which is typically beneficial to precious metals like gold and silver, as it would make them much cheaper.

In other developments, Sibanye Stillwater Limited (NYSE:SBSW) recently completed the acquisition of Metallix Refining for $78 million.

“The acquisition of Metallix strengthens and complements Sibanye-Stillwater’s existing US recycling operations and is expected to unlock significant value through cost and operational synergies across the combined businesses,” Sibanye Stillwater Limited (NYSE:SBSW) said.

5. BlackBerry Limited (NYSE:BB)

Shares of BlackBerry jumped by 17.8 percent week-on-week, as investor sentiment was generally bolstered by an impressive earnings performance in the second quarter of fiscal year 2026.

In an updated report, BlackBerry Limited (NYSE:BB) said it swung to a net income of $13.3 million from a $19.7 million net loss in the same period last year. Revenues exceeded its target, inching up by 2.7 percent to $129.6 million from $126.2 million year-on-year.

Encouraged by the results, BlackBerry Limited (NYSE:BB) raised its revenue growth forecast for the full fiscal period, now ranging from $519 million to $541 million, from the previous outlook of $508 million to $538 million.

Revenues from the QNX segment alone are expected to generate $256 million to $270 million, marking a higher lower-end target than the $250 million expected previously.

“BlackBerry made a strong start to the new fiscal year, building on the solid foundation we as a company have laid over the past year,” BlackBerry Limited (NYSE:BB) CEO John Giamatteo said.

“Both our QNX and Secure Communications divisions continue to execute effectively against their strategies, beating both top line and profitability expectations. BlackBerry’s solid balance sheet and plan for continuing profitability and cash generation this fiscal year enable us to allocate capital efficiently, with $10 million of share buybacks executed this past quarter,” he added.

4. Intel Corp. (NASDAQ:INTC)

Intel grew its share price by 20.01 percent week-on-week to hit a new all-time high as investor sentiment was boosted by news that it was courting Apple Inc. to invest in its business.

On Friday alone, Intel Corporation (INTC) soared to a new all-time high of $36.30 before trimming gains to finish the day just up by 4.44 percent at $35.50 apiece after announcements that it was courting Apple Inc. to invest as part of its efforts to bolster its revival and expansion program.

Initial negotiations are currently underway, with a focus on how to work more closely. Talks, however, could still fall through.

Earlier this month, Intel Corp. (NASDAQ:INTC) secured a $5 billion investment from chip giant Nvidia Corp., covering the development of AI infrastructures and personal computing products that accelerate applications and workloads across hyperscale, enterprise, and consumer markets.

Additionally, Intel Corp. (NASDAQ:INTC) and Nvidia will focus on seamlessly connecting their architectures using the latter’s NVLink, which would integrate the strengths of NVIDIA’s AI and accelerated computing with Intel’s leading CPU technologies and x86 ecosystem to deliver cutting-edge solutions for customers.

3. Fluence Energy, Inc. (NASDAQ:FLNC)

Shares of Fluence Energy soared by 27.2 percent week-on-week as investors loaded positions in industries that are expected to benefit from the booming artificial intelligence sector.

Additionally, sentiment was further supported by its bagging of a new deal to support a 133-MW battery energy storage system in Poland.

In a statement, Fluence Energy, Inc. (NASDAQ:FLNC) said its subsidiary was awarded by DRI, the European renewables arm of Ukraine’s DTEK Group, to supply battery storage units for the Trzebinia project in southern Poland.

The 622 MWh Trzebinia project is set to be the largest battery storage facility taking part in the Polish Capacity Market when batteries are integrated into the system from 2027. It will deploy Fluence Energy, Inc.’s (NASDAQ:FLNC) Smartstack platform—a modular, high-density system designed to enable fast deployment and optimized performance over an asset’s lifetime.

The announcement followed DTEK’s energization of a 200MW project across six sites in Ukraine using Fluence Energy, Inc.’s (NASDAQ:FLNC) storage systems.

The project is designed to make Ukraine’s energy system more resilient in time for winter.

2. Crinetics Pharmaceuticals, Inc. (NASDAQ:CRNX)

Shares of Crinetics Pharmaceuticals climbed by 35.39 percent week-on-week as investors gobbled up shares after the Food and Drug Administration (FDA) officially approved its drug treatment for acromegaly.

In a statement, Crinetics Pharmaceuticals, Inc. (NASDAQ:CRNX) said that it officially secured the green light of the FDA for its drug, Palsonify, for the first-line treatment of adults with acromegaly who had an inadequate response to surgery and those whose surgery is not an option.

The approval is based on data from the PATHFNDR-1 and PATHFNDR-2 Phase 3 pivotal trials, which evaluated the drug’s safety and efficacy in previously treated and medically untreated adults with acromegaly.

Across both trials, Palsonify consistently demonstrated rapid onset, reliable biochemical control, and sustained efficacy.

Crinetics Pharmaceuticals, Inc. (NASDAQ:CRNX) said it targets to bring Palsonify to the market in early October.

It is also underway with a marketing authorization application with the European Union to sell the drug across Europe, which is expected to be approved by next year.

The company is also partnering with Japanese firm Sanwa Kagaku Kenkyusho (SKK) to develop and commercialize paltusotine for acromegaly in Japan.

1. uniQure NV (NASDAQ:QURE)

uniQure soared by 291 percent week-on-week to climb to a new all-time high as investors cheered the stellar performance of its potential drug treatment for Huntington’s disease.

In Friday’s session, uniQure NV (NASDAQ:QURE) soared to its highest 52-week price of $55.11 before trimming gains to end the day just up by 3.15 percent at $54.31 apiece.

This followed an announcement on the same day that its potential treatment slowed progression of Huntington’s disease by 75 percent after 36 months.

Uniqure NV (NASDAQ:QURE) said the drug candidate, AMT-130, was well-tolerated and that no adverse effects have been observed since 2022.

The company said that the Food and Drug Administration (FDA) has granted AMT-130 Breakthrough Therapy and Regenerative Medicine Advanced Therapy (RMAT) designations.

“We are incredibly excited about these topline results and what they may represent for individuals and families affected by Huntington’s disease,” said Uniqure NV (NASDAQ:QURE) Chief Medical Officer Walid Abi-Saab.

“These findings reinforce our conviction that AMT-130 has the potential to fundamentally transform the treatment landscape for Huntington’s disease, while also providing important evidence supporting one-time, precision-delivered gene therapies for the treatment of neurological disorders,” he noted.

While we acknowledge the potential of QURE to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than QURE and that has 100x upside potential, check out our report about this cheapest AI stock.

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