In this article, we will look at the 10 Best NASDAQ Stocks with Huge Upside Potential.

On September 13, Warren Pies, 3Fourteen Research Co-Founder, appeared on a CNBC interview to discuss the markets amid expectations of a Federal Reserve rate cut next week.

Warren Pies expressed cautious optimism, noting a bullish stance on the market with a price target of 6800 for the S&P 500. However, he warned that most of the positive sentiment is already priced in due to the expected 25 basis point cut. His key focus is on the Fed’s September economic projections, specifically the guidance on rates for the end of 2026.

He noted that currently, there is a gap between market expectations and the Fed’s projections. If the Fed’s update does not align with market hopes, there is a possibility of disappointment, a spike in rates, and a market pullback. Pies acknowledged this could create some volatility next week but maintained a generally bullish outlook.

While talking about asset allocation, Pies suggests balancing equity risk with a significant bond position, even if that view is out of consensus. He argues the labor market is showing real signs of weakness beyond supply factors such as immigration. This weakening labor situation poses a growth risk to equities.

Pies believes that holding bonds to offset equity risk is prudent. He expects the 10-year Treasury yield to drop below 4%. He explains that last year’s rate-cut cycle was unusual because the yield curve began deeply inverted, reflecting strong recession fears. However, this year, the yield curve is positively sloped, indicating healthier conditions. As the Fed cuts rates this cycle, yields across the curve should fall, pushing yields lower. Thereby results in a more typical bond market reaction. ​

With that, let’s take a look at the 10 best NASDAQ stocks with huge upside potential.

Our Methodology

To curate the list of 10 best NASDAQ stocks with huge upside potential, we used the Finviz Stock Screener to aggregate a list of NASDAQ stocks with more than 30% upside from current levels. Next, we cross-checked the upside potential from CNN and ranked the stocks in ascending order of this metric. We have also added the hedge fund sentiment, sourced from Insider Monkey’s Q2 2025 database. Please note that the data was recorded on September 11, 2025.

​​​​Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 373.4% since May 2014, beating its benchmark by 218 percentage points (see more details here).

10 Best NASDAQ Stocks with Huge Upside Potential

10. Tradeweb Markets Inc. (NASDAQ:TW)

Number of Hedge Fund Holders: 34

Analyst Upside Potential: 30.79%

Tradeweb Markets Inc. (NASDAQ:TW) is one of the Best NASDAQ Stocks to Buy with Huge Upside Potential. On September 8, Michael Cyprys from Morgan Stanley maintained a Hold rating on Tradeweb Markets Inc. (NASDAQ:TW) with a price target of $149.

The analyst noted that he maintained a Hold rating due to the mixed operational signals from the company. He highlighted that the company’s average daily volumes for August grew by 11% year-over-year. However, this growth is slower compared to the 17% growth in July. In addition, the quarter-to-date volumes are also below both Morgan Stanley’s and consensus forecasts.

Moreover, Cyprus noted that Tradeweb Markets Inc. (NASDAQ:TW) gained market share year-over-year in investment-grade and high-yield credit. However, the month-over-month figures show a decline in market share. Similarly, the credit volumes overall also fell short of expectations. As a result of these mixed results, the analyst remains cautious about the company due to the near-term uncertainties.

Tradeweb Markets Inc. (NASDAQ:TW) operates electronic marketplaces for trading financial assets. Its technology supports multiple asset classes and global markets.

9. Intuitive Surgical, Inc. (NASDAQ:ISRG)

Number of Hedge Fund Holders: 107

Analyst Upside Potential: 32.67%

Intuitive Surgical, Inc. (NASDAQ:ISRG) is one of the Best NASDAQ Stocks to Buy with Huge Upside Potential. On September 10, Travis Steed from Bank of America Securities maintained a Buy rating on Intuitive Surgical, Inc. (NASDAQ:ISRG) with a price target of $650.

The analyst noted several factors supporting his bullish sentiment, including the company’s effort to grow its total addressable market, which has expanded from 1.8 million procedures in 2009 to around 8 million procedures in 2025. The analyst expects this growth to stay persistent, particularly in cardiovascular procedures.

In addition, Steed highlighted that Intuitive Surgical, Inc. (NASDAQ:ISRG) is tapping into the cardiovascular opportunity and has hired a head of cardio and has multiple job postings for cardiovascular sales managers.

Lastly, the analyst noted that the company is advancing its technology and has introduced force feedback and enhanced visualization features in the da Vinci 5 (dV5) system. These innovations aim to boost the adoption of robotic procedures in cardiovascular surgeries.

Intuitive Surgical, Inc. (NASDAQ:ISRG) develops and markets robotic surgical systems, including the da Vinci surgical system and the Ion endoluminal system.