Orbimed Advisors Llc

Insider Trading: Sales

Symbol	Price	Amount	Total Value	Remaining Holdings	Date	Form 4
SIEN	$5.98	2,785	$16,654.30	17,100	2015-10-12	Filing
SIEN	$5.98	285,106	$1,704,933.88	1,767,902	2015-10-12	Filing
SIEN	$7.03	2,041	$14,348.23	19,885	2015-10-09	Filing
SIEN	$7.03	210,668	$1,480,996.04	2,053,008	2015-10-09	Filing
SIEN	$7.24	3,837	$27,779.88	21,926	2015-10-08	Filing
SIEN	$7.24	396,163	$2,868,220.12	2,263,676	2015-10-08	Filing
SIEN	$7.36	454	$3,341.44	25,763	2015-10-07	Filing
SIEN	$7.36	53,446	$393,362.56	2,659,839	2015-10-07	Filing
SIEN	$7.80	59	$460.20	26,217	2015-10-06	Filing
SIEN	$7.80	6,941	$54,139.80	2,713,285	2015-10-06	Filing
SIEN	$8.19	1,163	$9,524.97	26,276	2015-10-05	Filing
SIEN	$8.19	136,937	$1,121,514.03	2,720,226	2015-10-05	Filing
SIEN	$10.34	403	$4,167.02	27,439	2015-10-02	Filing
SIEN	$10.34	47,497	$491,118.98	2,857,163	2015-10-02	Filing
SIEN	$10.34	400	$4,136.00	27,842	2015-10-01	Filing
SIEN	$10.34	47,100	$487,014.00	2,904,660	2015-10-01	Filing
SIEN	$10.17	369	$3,752.73	28,242	2015-09-30	Filing
SIEN	$10.17	43,471	$442,100.07	2,951,760	2015-09-30	Filing
SIEN	$10.08	89	$897.12	28,611	2015-09-29	Filing
SIEN	$10.08	10,469	$105,527.52	2,995,231	2015-09-29	Filing