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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1649904	Rhythm Pharmaceuticals Inc.	RYTM	()	4

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1385155	P David Meeker	C/O Rhythm Pharmaceuticals, Inc. 222 Berkeley Street, 12Th Floor Boston MA 02116	President And Ceo	Yes	Yes	No	No

Transaction Summary

Sold:	43,620 shares	Avg. Price: $65.05	Total Value: $2,837,333.35
Number of Shares After Transactions:	201,825 shares

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2025-06-03	43,620	$4.59	245,445	No	4	M	Direct
Common Stock	Disposition	2025-06-03	43,346	$65.04	202,099	No	4	S	Direct
Common Stock	Disposition	2025-06-03	274	$65.60	201,825	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (Right to Buy)	Disposition	2025-06-03	43,620	$0.00	43,620	$4.59

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0		2025-11-16	No	4	M	Direct

Footnotes

Includes 544 additional shares acquired under the Issuer's Employee Stock Purchase Plan.
The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 plan adopted by the Reporting Person on March 3, 2025.
The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $64.59 to $65.58 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $65.60 to $65.61 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
The stock option is fully vested.