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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1242825	M Jeffrey Leiden	C/O Vertex Pharmaceuticals Incorporated 50 Northern Avenue Boston MA 02210	Executive Chairman	Yes	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2023-05-05	708	$349.38	36,683	No	4	S	Direct
Common Stock	Disposition	2023-05-05	171	$350.30	36,512	No	4	S	Direct
Common Stock	Disposition	2023-05-08	1,125	$349.00	35,387	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	440	Indirect	401(k)

Footnotes

Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 11/01/2022.
Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Open market sales reported on this line occurred at a weighted average price of $349.38 (range $349.00 to $349.95).
Open market sales reported on this line occurred at a weighted average price of $350.30 (range $350.12 to $350.40).