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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1789815	Ourania Tatsis	C/O Vertex Pharmaceuticals Incorporated 50 Northern Avenue Boston MA 02210	Evp, Chief Reg. & Quality Off.	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2023-02-17	4,498	$292.85	60,947	No	4	F	Direct
Common Stock	Disposition	2023-02-21	4	$291.01	60,943	No	4	S	Direct
Common Stock	Disposition	2023-02-21	145	$292.85	60,798	No	4	S	Direct
Common Stock	Disposition	2023-02-21	207	$293.83	60,591	No	4	S	Direct
Common Stock	Disposition	2023-02-21	124	$294.77	60,467	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	F	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct

Footnotes

Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.
Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Open market sales reported on this line occurred at a weighted average price of $292.85 (range $292.37 to $293.36).
Open market sales reported on this line occurred at a weighted average price of $293.83 (range $293.39 to $294.38).
Open market sales reported on this line occurred at a weighted average price of $294.77 (range $294.42 to $295.37).