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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1789815	Ourania Tatsis	C/O Vertex Pharmaceuticals Incorporated 50 Northern Avenue Boston MA 02210	Evp, Chief Reg. & Quality Off.	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2023-02-14	71	$295.89	65,694	No	4	S	Direct
Common Stock	Disposition	2023-02-14	20	$296.48	65,674	No	4	S	Direct
Common Stock	Disposition	2023-02-14	43	$297.98	65,631	No	4	S	Direct
Common Stock	Disposition	2023-02-14	135	$299.60	65,496	No	4	S	Direct
Common Stock	Disposition	2023-02-14	51	$300.58	65,445	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct

Footnotes

Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.
Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Open market sales reported on this line occurred at a weighted average price of $295.89 (range $295.36 to $296.32).
Open market sales reported on this line occurred at a weighted average price of $297.98 (range $297.50 to $298.48).
Open market sales reported on this line occurred at a weighted average price of $299.60 (range $299.19 to $300.16).
Open market sales reported on this line occurred at a weighted average price of $300.58 (range $300.34 to $301.01).