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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1408443	Milestone Pharmaceuticals Inc.	MIST	Pharmaceutical Preparations (2834)	000000000

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1493215	Rtw Investments, Lp	40 10Th Avenue 7Th Floor New York NY 10014		No	No	Yes	No
1493280	Roderick Wong	C/O Rtw Investments, Lp 40 10Th Avenue, 7Th Floor New York NY 10014		No	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Shares, No Par Value ("Common Shares")	Acquisiton	2022-09-07	1,557,346	$8.71	4,315,102	No	4	P	Indirect	See footnote
Common Shares	Disposition	2022-09-07	1,557,346	$8.71	4,315,102	No	4	S	Indirect	See footnote

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Indirect	See footnote
No	4	S	Indirect	See footnote

Footnotes

Ordinary course rebalancing transactions in which certain RTW Funds (as defined below) rebalance holdings of the Issuer among the RTW Funds. After the transactions reported herein, the amount of Common Shares of the Issuer beneficially owned in the aggregate by the Reporting Persons did not change.
This Form 4 is being filed by each of (i) RTW Investments, LP (the "Adviser") with respect to Common Shares held by certain investment funds managed by the Adviser (the "RTW Funds"), and (ii) Roderick Wong, M.D., who serves as the Managing Partner and Chief Investment Officer of the Adviser.