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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1626199	Alpine Immune Sciences Inc.	ALPN	()	4

Insiders

Cik	Name	Reported Address	Director	Officer	Large Shareholder	Other
1341382	N James Topper	C/O Frazier Healthcare Partners 601 Union Street, Suite 3200 Seattle WA 98101	Yes	No	Yes	No
1365617	J Patrick Heron	C/O Frazier Healthcare Partners 601 Union Street, Suite 3200 Seattle WA 98101	No	No	Yes	No
1655827	Frazier Life Sciences Viii, L.p.	C/O Frazier Healthcare Partners 601 Union Street, Suite 3200 Seattle WA 98101	No	No	Yes	No
1698755	Fhm Life Sciences Viii, L.p.	C/O Frazier Healthcare Partners 601 Union Street, Suite 3200 Seattle WA 98101	No	No	Yes	No
1698823	Fhm Life Sciences Viii, L.l.c.	C/O Frazier Healthcare Partners 601 Union Street, Suite 3200 Seattle WA 98101	No	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2022-02-11	112,665	$7.10	1,484,115	No	4	P	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Direct

Footnotes

The reportable securities are held directly by Frazier Life Sciences VIII, L.P. ("FLS LP"). FHM Life Sciences VIII, L.P. ("FHM LP") is the general partner of FLS LP. FHM Life Sciences VIII, L.L.C. ("FHM LLC") is the general partner of FHM LP. James N. Topper and Patrick J. Heron are the sole managing members of FHM LLC. Mr. Topper, Mr. Heron, FHM LP and FHM LLC disclaims beneficial ownership of the securities held by FLS LP except, to the extent of his or its pecuniary interest therein, if any.