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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1683553	Spruce Biosciences Inc.	SPRB	Pharmaceutical Preparations (2834)	812154263

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1822557	V Camilla Simpson	C/O Spruce Biosciences, Inc. 2001 Junipero Serra Blvd., Suite 640 Daly City CA 94014		Yes	No	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2021-05-20	334	$0.85	334	No	4	M	Direct
Common Stock	Disposition	2021-05-20	334	$15.29	0	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (Right to Buy)	Disposition	2021-05-20	334	$0.00	2,007	$0.85
Common Stock	Stock Option (Right to Buy)	Acquisiton	2021-05-20	10,000	$0.00	10,000	$15.24

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
1,673		2027-10-18	No	4	M	Direct
10,000		2031-05-19	No	4	A	Direct

Footnotes

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.
The shares subject to the stock option vest over a four-year period commencing October 19, 2017, with 1/4th of the shares vesting on October 19, 2018 and 1/36th of the remaining shares vesting on a monthly basis.
The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2022 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).