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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1503802	Karyopharm Therapeutics Inc.	KPTI	Pharmaceutical Preparations (2834)	263931704

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1603510	Brett Christopher Primiano	C/O Karyopharm Therapeutics Inc. 85 Wells Avenue Newton MA 02459	Evp, Cbo, Gc & Secretary	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2020-12-01	78,124	$10.45	82,647	No	4	M	Direct
Common Stock	Disposition	2020-12-01	78,124	$17.66	4,523	No	4	S	Direct
Common Stock	Acquisiton	2020-12-01	58,937	$10.39	63,460	No	4	M	Direct
Common Stock	Disposition	2020-12-01	58,937	$17.35	4,523	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (right to buy)	Disposition	2020-12-01	78,124	$0.00	78,124	$10.45
Common Stock	Stock Option (right to buy)	Disposition	2020-12-01	58,937	$0.00	58,937	$10.39

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
46,876		2028-01-23	No	4	M	Direct
16,842		2027-01-19	No	4	M	Direct

Footnotes

These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on January 24, 2019, with the remaining 75% vesting in 36 equal monthly installments thereafter.
This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on January 20, 2018, with the remaining 75% vesting in 36 equal monthly installments thereafter.