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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1503802	Karyopharm Therapeutics Inc.	KPTI	()	4

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1364719	Michael Kauffman	C/O Karyopharm Therapeutics Inc. 85 Wells Avenue Newton MA 02459	Chief Executive Officer	Yes	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2019-11-01	10,000	$4.75	539,767	No	4	M	Direct
Common Stock	Disposition	2019-11-01	10,000	$12.00	529,767	No	4	S	Direct
Common Stock	Acquisiton	2019-11-01	10,000	$4.75	741,134	No	4	M	Indirect	By Spouse
Common Stock	Disposition	2019-11-01	10,000	$12.00	731,134	No	4	S	Indirect	By Spouse

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct
No	4	M	Indirect	By Spouse
No	4	S	Indirect	By Spouse

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (right to buy)	Disposition	2019-11-01	10,000	$0.00	10,000	$4.75
Common Stock	Stock Option (right to buy)	Disposition	2019-11-01	10,000	$0.00	10,000	$4.75

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
416,061		2023-09-02	No	4	M	Direct
460,303		2023-09-02	No	4	M	Indirect

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	29,685	Indirect	By GRAT
Common Stock	29,685	Indirect	By Spouse's GRAT

Footnotes

These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.
These shares are held by the Michael G. Kauffman 2016 Qualified Annuity Interest Trust.
These shares are held by the Sharon Shacham 2016 Qualified Annuity Interest Trust.
This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on September 3, 2014, and the remaining 75% vested in 36 equal monthly installments thereafter.