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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1674365	Aptinyx Inc.	APTX	()	4

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1341382	N James Topper	C/O Aptinyx Inc. 909 Davis Street, Suite 600 Evanston IL 60201		Yes	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2018-06-25	1,047,450	$0.00	1,047,450	No	4	C	Indirect	See Footnote
Common Stock	Acquisiton	2018-06-25	1,197,076	$0.00	2,244,526	No	4	C	Indirect	See Footnote
Common Stock	Acquisiton	2018-06-25	795,553	$0.00	3,040,079	No	4	C	Indirect	See Footnote
Common Stock	Acquisiton	2018-06-25	150,000	$16.00	3,190,079	No	4	P	Indirect	See Footnote

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	C	Indirect	See Footnote
No	4	C	Indirect	See Footnote
No	4	C	Indirect	See Footnote
No	4	P	Indirect	See Footnote

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Series A-1 Convertible Preferred Stock	Disposition	2018-06-25	28,895,188	$0.00	1,047,450	$0.00
Common Stock	Series A-2 Convertible Preferred Stock	Disposition	2018-06-25	33,022,786	$0.00	1,197,076	$0.00
Common Stock	Series B Convertible Preferred Stock	Disposition	2018-06-25	21,946,301	$0.00	795,553	$0.00

Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
No	4	C	Indirect
No	4	C	Indirect
No	4	C	Indirect

Footnotes

Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.
The shares are held directly by Frazier Life Sciences VIII, L.P. ("FLS-VIII"). FHM Life Sciences VIII, L.P. ("FHM-VIII L.P.") serves as the sole general partner of FLS-VIII and owns no shares directly. FHM Life Sciences VIII, LLC ("FHM-VIII LLC") serves as the sole general partner of FHM-VIII L.P. and owns no shares directly. James N. Topper and Patrick Heron are members of FHM-VIII LLC and share voting and dispositive power over the shares held by FLS-VIII; however, they disclaim beneficial ownership of the shares held by FLS-VIII except to the extent of their pecuniary interests therein.
On June 25, 2018, FLS-VIII purchased 150,000 shares of common stock of the Issuer at a price of $16.00 per share pursuant to an underwritten public offering.