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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1557290	A Stuart Arbuckle	C/O Vertex Pharmaceuticals Incorporated 50 Northern Avenue Boston MA 02210	Evp\Chief Commercial Officer	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2017-10-27	4,165	$141.41	116,952	No	4	S	Direct
Common Stock	Acquisiton	2017-10-27	2,125	$96.87	119,077	No	4	M	Direct
Common Stock	Disposition	2017-10-27	2,125	$149.00	116,952	No	4	S	Direct
Common Stock	Disposition	2017-10-31	11,617	$142.18	105,335	No	4	S	Direct
Common Stock	Disposition	2017-10-31	5,600	$143.54	99,735	No	4	S	Direct
Common Stock	Disposition	2017-10-31	25,999	$144.54	73,736	No	4	S	Direct
Common Stock	Disposition	2017-10-31	17,501	$145.34	56,235	No	4	S	Direct
Common Stock	Disposition	2017-10-31	7,783	$146.61	48,452	No	4	S	Direct
Common Stock	Disposition	2017-10-31	5,000	$147.87	43,452	No	4	S	Direct
Common Stock	Disposition	2017-10-31	1,000	$148.54	42,452	No	4	S	Direct
Common Stock	Disposition	2017-10-31	500	$149.34	41,952	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (Right to Buy)	Disposition	2017-10-27	2,125	$0.00	2,125	$96.87

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
6,375		2024-07-14	No	4	M	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	140	Indirect	401(k)

Footnotes

Transaction made pursuant to Mr. Arbuckle's company-approved trading plan under Rule 10b5-1.
Open market sales reported on this line occurred at a weighted average price of $142.18 (range $141.83 to $142.74).
Mr. Arbuckle undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Open market sales reported on this line occurred at a weighted average price of $143.54 (range $143.03 to $144.02).
Open market sales reported on this line occurred at a weighted average price of $144.54 (range $144.04 to $145.01).
Open market sales reported on this line occurred at a weighted average price of $145.34 (range $145.05 to $145.87).
Open market sales reported on this line occurred at a weighted average price of $146.61 (range $146.20 to $147.18).
Open market sales reported on this line occurred at a weighted average price of $147.87 (range $147.22 to $148.20).
Open market sales reported on this line occurred at a weighted average price of $148.54 (range $148.25 to $149.18).
The option vests in 16 quarterly installments from 7/15/2014.