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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1649904	Rhythm Pharmaceuticals Inc.	RYTM	()	I0

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1370483	Ipsen, S.a.	65 Quai Georges Gorse Boulogne-Billancourt I0 92100		No	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2017-10-10	45,831	$0.00	645,161	No	4	C	Indirect	The owner of record of the securities is Sutrepa SAS. Sutrepa SAS is controlled by Ipsen SA
Common Stock	Acquisiton	2017-10-10	167,938	$0.00	813,099	No	4	C	Indirect	The owner of record of the securities is Sutrepa SAS. Sutrepa SAS is controlled by Ipsen SA
Common Stock	Acquisiton	2017-10-10	20,000	$17.00	833,099	No	4	P	Indirect	The owner of record of the securities is Ipsen Pharma, S.A.S., which is controlled by Ipsen SA

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	C	Indirect	The owner of record of the securities is Sutrepa SAS. Sutrepa SAS is controlled by Ipsen SA
No	4	C	Indirect	The owner of record of the securities is Sutrepa SAS. Sutrepa SAS is controlled by Ipsen SA
No	4	P	Indirect	The owner of record of the securities is Ipsen Pharma, S.A.S., which is controlled by Ipsen SA

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Series A-1 Junior Preferred Stock	Disposition	2017-10-10	45,831	$0.00	45,831	$0.00
Common Stock	Series A Convertible Preferred Stock	Disposition	2017-10-10	167,938	$0.00	167,938	$0.00

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0			No	4	C	Indirect
0			No	4	C	Indirect

Footnotes

In connection with the closing of the Issuer's initial public offering, each share of the Issuer's series A convertible preferred stock (the "Series A Preferred") and series A-1 junior preferred stock (the "Series A-1 Preferred") converted into the Issuer's common stock on a 9.17-for-one basis without payment or consideration. The Series A Preferred and the Series A-1 Preferred had no expiration date.
Reflects the number of shares of Series A Preferred and Series A-1 Preferred, as applicable, held by the Reporting Person on an as-converted to common stock basis.