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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1597264	Blueprint Medicines Corp	BPMC	Pharmaceutical Preparations (2834)	000000000

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
315066	Fmr Llc	245 Summer Street Boston MA 02210		No	No	Yes	Yes

Transaction Summary

Sold:	28,684 shares	Avg. Price: $20.83	Total Value: $597,544.33
Number of Shares After Transactions:	1,168,597 shares

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Disposition	2015-11-16	23,785	$20.78	1,173,496	No	4	S	Indirect	Shares held by persons and entities whose shares are subject to reporting by the undersigned.
Common Stock	Disposition	2015-11-16	1,820	$21.41	1,171,676	No	4	S	Indirect	Shares held by persons and entities whose shares are subject to reporting by the undersigned.
Common Stock	Disposition	2015-11-16	300	$22.02	1,171,376	No	4	S	Indirect	Shares held by persons and entities whose shares are subject to reporting by the undersigned.
Common Stock	Disposition	2015-11-16	2,779	$20.77	1,168,597	No	4	S	Indirect	Shares held by persons and entities whose shares are subject to reporting by the undersigned.

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	S	Indirect	Shares held by persons and entities whose shares are subject to reporting by the undersigned.
No	4	S	Indirect	Shares held by persons and entities whose shares are subject to reporting by the undersigned.
No	4	S	Indirect	Shares held by persons and entities whose shares are subject to reporting by the undersigned.
No	4	S	Indirect	Shares held by persons and entities whose shares are subject to reporting by the undersigned.

Footnotes

The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $20.00 to $20.99. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $21.01 to $21.82. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $20.08 to $20.90. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.