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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1206369	Iii Joseph Klein	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010		Yes	No	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2015-03-05	3,750	$9.22	4,845	No	4	M	Direct
Common Stock	Acquisiton	2015-03-05	3,750	$9.30	8,595	No	4	M	Direct
Common Stock	Acquisiton	2015-03-05	2,500	$12.94	11,095	No	4	M	Direct
Common Stock	Disposition	2015-03-05	7,000	$70.95	4,095	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	M	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Director Stock Option (right to buy)	Disposition	2015-03-05	3,750	$0.00	3,750	$9.22
Common Stock	Director Stock Option (right to buy)	Disposition	2015-03-05	3,750	$0.00	3,750	$9.30
Common Stock	Director Stock Option (right to buy)	Disposition	2015-03-05	2,500	$0.00	2,500	$12.94

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0	2014-07-01	2020-06-30	No	4	M	Direct
3,750	2012-07-01	2021-06-30	No	4	M	Direct
5,937	2013-07-02	2022-07-01	No	4	M	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	100	Indirect	By son

Footnotes

Acquired as a result of exercising a stock option.
The sale was a result of shares owned. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.8500 to $71.0300, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.
Grant of 7/1/2011 to reporting person of stock options under the Isis Pharmacueticals, Inc. Amended & Restated 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on 7/1/2012. The option shal be fully vested and exercisable on 7/1/2015. Following the reported option exercise, the option was exercisable as to 0 shares on 3/5/2015.
The sale was made pursuant to shares owned.
Grant of 7/2/2012 to reporting person of stock options under the Isis Pharmacueticals, Inc. Amended & Restated 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on 7/2/2013. The option shal be fully vested and exercisable on 7/2/2016. Following the reported option exercise, the option was exercisable as to 313 shares on 3/5/2015.