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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
729922	Osi Pharmaceuticals Inc	OSIP	In Vitro & In Vivo Diagnostic Substances (2835)	133159796

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1225199	Colin Goddard	C/O Osi Pharmaceuticals, Inc. 41 Pinelawn Road Melville NY 11747	Chief Executive Officer	Yes	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2010-03-01	66,000	$23.25	224,265	No	4	M	Direct
Common Stock	Disposition	2010-03-01	66,000	$55.17	158,265	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (Right to Buy)	Disposition	2010-03-01	66,000	$0.00	66,000	$23.25

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
34,000	2001-06-21	2010-06-21	No	4	M	Direct

Footnotes

Transaction made pursuant to a 10b5-1 trading plan adopted November 7, 2009. Transaction occured upon exercise of options due to expire on June 21, 2010.
The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $55.11 to $55.30 per share. The Reporting Person will provide, upon request of the staff of the U.S. Securities and Exchange Commission, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
One third of the stock options became exercisable on 6/21/2001 and the remainder vested ratably on a monthly basis over the succeeding 24 months.
Includes only options with the same termination date.