| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1.) | Palo Alto Investors William Leland Edwards |
1,938,824 | $146,439 | -5% |
17.15% |
| 2.) | Sectoral Asset Management J�R�Me Pfund And Michael Sj�Str�M |
1,925,184 | $145,409 | +4% |
5.08% |
| 3.) | Orbimed Advisors Samuel Isaly |
1,419,300 | $107,200 | -7% |
3.3% |
| 4.) | 29,459,000 | $60,082 | +57% |
2.81% | |
| 5.) | 9,000,000 | $18,236 |  |
2.06% | |
| 6.) | 10,000,000 | $20,244 | |
1.81% | |
| 7.) | 650,000 | $49,095 | -13% |
1.8% | |
| 8.) | 600,000 | $45,318 | |
1.66% | |
| 9.) | 22,010,000 | $44,557 |  |
0.7% | |
| 10.) | 100,000 | $7,553 | |
0.47% | |
| 11.) | 67,700 | $5,114 | |
0.33% | |
| 12.) | Point State Capital Sean Cullinan |
280,000 | $21,148 | |
0.31% |
| 13.) | Baker Bros. Advisors Julian Baker And Felix Baker |
159,652 | $12,059 | -26% |
0.31% |
| 14.) | Columbus Circle Investors Donald Chiboucis |
363,893 | $27,485 | -38% |
0.22% |
| 15.) | Kingdon Capital Mark Kingdon |
45,100 | $3,406 | |
0.21% |
| 16.) | Driehaus Capital Richard Driehaus |
50,320 | $3,801 | +5% |
0.14% |
| 17.) | Pentwater Capital Management Matthew Halbower |
53,861 | $4,068 | +173% |
0.14% |
| 18.) | Adage Capital Management Phill Gross And Robert Atchinson |
529,042 | $39,959 | -58% |
0.14% |
| 19.) | Sigma Capital Management Sac Subsidiary |
25,290 | $1,910 | +11% |
0.1% |
| 20.) | Hbk Investments David Costen Haley |
63,494 | $4,796 | +189% |
0.09% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $97.13 | 1,194 | Officer | 32,083 | 2013-05-14 | Filing | |
| $96.38 | 2,988 | Officer | 33,277 | 2013-05-14 | Filing | |
| $97.26 | 1,000 | Officer | 47,646 | 2013-05-13 | Filing | |
| $98.28 | 2,500 | Officer | 48,646 | 2013-05-13 | Filing | |
| $98.78 | 3,000 | Officer | 51,146 | 2013-05-13 | Filing |
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